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Chronic stress accelerates the process of gastric precancerous lesions in rats. Cantonese dogs doing defamation crimes are attempting to kill me. Pui!
- Thread starter ginfreely
- Start date
Don't wait! Quickly go kitchen take a knife and fuck yourself in the hole below.
There will be fireworks when you die. Gansiokbin you old chaocheebye.
Cantonese dogs @musclepower @gsbslut @Balls2U @Cottonmouth etc you think you act innocent don’t answer my question only can deny you are criminals doing defamation crimes to me and you are murderers attempting to kill me? Heaven got eyes and will serve karma on you and your cheap chicken family women Pui!!
May you Cantonese dogs @musclepower @gsbslut @Cottonmouth @Balls2U and your cheap family women be gangraped and that’s called Justice for the harm you inflicted and still inflicting on me. Pui!
Background: Gastrointestinal cancers account for 20% of all deaths worldwide. Gastric cancer (GC) patients are susceptible to psychological change, especially depression which is commonly induced by chronic stress. Gastric precancerous lesions (GPL) is an important prodromal stage in the occurrence of gastric cancer. Chronic stress influences the prognosis of GC and may influence the process of GPL as well.
Methods: Sixty SD rats were randomly divided into a control group, GPL group, and GPL+CUMS group. In the GPL group, 200μg/mL N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) free drinking method combined with intermittent fasting was applied to establish the GPL animal model. Based on this, we combined the GPL rats with chronic unpredicted mild stress (CUMS) to establish a comprehensive model. We then evaluated their behavior by open field tests and sucrose preference tests. We tested the IL-6, IL-10, TNF-α, Ghrelin, Leptin and Somatostatin (SS) levels in serum and observed the expression of Ghrelin and Gastrokine 2(GKN2) in the gastric mucosa of rats with tumors by immunofluorescence.
Results: Our results showed that GPL and GPL+CUMS rats all displayed a significantly decreased total distance and mean velocity traveled in the open field test. The percentages of sucrose preference were significantly decreased in the GPL+CUMS group compared to the control group. In addition, IL-6 and TNF-α were significantly increased in both the GPL and GPL+CUMS groups. Furthermore, the GPL+CUMS group showed significantly increased TNF-α levels in serum compared to the GPL rats. Our results showed that the expression of NF-κB, p53, and BCL-2 were significantly increased while BAX was reduced in the GPL and GPL+CUMS groups. Moreover, Ghrelin and Leptin levels in serum were significantly decreased in the GPL and GPL+CUMS groups. SS levels in serum were significantly increased in the GPL+CUMS group. Additionally, we found that the GPL+CUMS rats with tumors not only had strong expression of GKN2 on the luminal side and the lamina propria of the gastric mucosa and tumor, but also had expression of Ghrelin on the luminal side of the gastric mucosa. The areas that showed strong expression of GKN2 and Ghrelin, are all located around the blood vessels in the tumor.
Conclusions: GPL rats under chronic stress would aggravate the conditions of GPL, shorten the process of GPL, and increase the risk of tumorigenesis. In addition, the close monitoring of the mental health of cancer survivors and precancerous lesion patients is suggested to be of great significance in the prevention and treatment of cancer.
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You fucking cheebye will be struck by lightning! Your corpse will be gang raped! Cut off your cheebye and send the whole piece to India!
Ganslutbin, you will reincarnate as a whore again to be fucked by millions. Fucking slut!
Cantonese dogs @musclepower @gsbslut@Balls2U @Cottonmouth etc you think you act innocent don’t answer my question only can deny you are criminals doing defamation crimes to me and you are murderers attempting to kill me? Heaven got eyes and will serve karma on you and your cheap chicken family women Pui!!
Dishonest dishonorable Cantonese dogs sons of prostitutes repeating lies that I send my mother to nursing home to win. 说谎精is you as usual whatever Cantonese dogs accused me is always what you are yourselves. Pui!
As usual Cantonese dogs @gsbslut @musclepower etc prove themselves dogs abusers murderers out to murder me and they are dogs with not an ounce of human kindness
Thread 'What are the duties of a sugar baby?'
https://www.sammyboy.com/threads/what-are-the-duties-of-a-sugar-baby.359877/
Thread 'What are the duties of a sugar baby?'
https://www.sammyboy.com/threads/what-are-the-duties-of-a-sugar-baby.359877/
And these shameless Malaysian and Malaysian origin Cantonese dogs abusers murderers @gsbslut @musclepower act like emperor demand that you take photo of your cb your nipple open leg to prove virginity to them if not accuse you 大话精. They tell evil toxic lies to harm people and you don’t prove to them is called you are 大话精and not they are 大话精。That’s how evil and vicious Malaysians are.
Up up up Cantonese dogs @musclepiwer @gsbslut @Cottonmouth etc proving themselves dogs and proud murderers scammers bullies with not a shred of human kindness. May they be reincarnated as women and be gangraped. Pui!!
You evil coward despicable Cantonese SCAMMER MURDERER ABUSER know you are hiding in rat hole telling evil toxic lies dare not swear say until like you won’t die and I am dying and that’s why I not scared of violent death. So shameless LIAR CRIMINAL BULLY SON OF CHICKEN HIDING IN RAT HOLE MALAYSIAN CANTONESE GANGSTER PUI!
Up up up Cantonese dogs @musclepower @gsbslut @Cottonmouth etc proving themselves dogs and proud murderers scammers bullies with not a shred of human kindness. May they be reincarnated as women and be gangraped. Pui!!
Tsk tsk tsk everything you accused me is what your cheap Cantonese mother wife daughters are. I am a virgin with annulled marriage of course means I am a virgin prior to marriage. You Cantonese dog son of prostitute hide in rat hole do defamation crimes to me that’s why you dare not swear scared to die a violent death. Hey proud murderer you think you don’t swear only heaven got no eyes to see you are doing daily stress to cause me cancer and will serve you karma? I will see how you die. Pui!
Tsk tsk tsk you Cantonese dog son of Malaysian pahang prostitute proud murderer criminal bully gangster hiding in rat hole doing defamation crimes to Gansiokbin and extorting evidence from your victom of crimes i see how you die. All evidence of science pointing to the FACT you Cantonese dogs are murderer. Pui!
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