- Joined
- Aug 6, 2008
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i realised many of you have a misunderstanding here that we are not able to know fully our body because we did not fully know the genome of human. this is a bit technical, but for education purpose if you want to know... carry on reading.
actually we already politically finished (declared by the politicians, till at later date everyone dig out the shit that it is actually unfinished) mapping the DNA genome of human (actually about 2 percent unfinished and those 2 are the tough nuts to crack). more or less we can traced what happened at genome to transcriptome level if we want. technically doable.
but in recent years, its discovered that many disease are actually epigenetic related, nothing got to do with mutation at the genome. it has more got to do with acetylation, phosphorylation, methylation of histones groups that is warping the chromosome. these epigenetic modification affects genes regulations - making of certain protein or suppression of it. that in terms give rises/maybe give a mechanism of cure to certain disease. epigenetic gives a plastic views of gene regulation that can accounts for environmental factors, like how the environments affects the acetylation, phosphorylation, methylation of histones proteins.
the unknown portion here to us is to know and understand the epigenetic pattern of these histone proteins, healthy vs disease. technically its difficult, eg need to find and developed specific antibodies to recognise those sites we want to study for enrichment.
this the summary
bow.
actually we already politically finished (declared by the politicians, till at later date everyone dig out the shit that it is actually unfinished) mapping the DNA genome of human (actually about 2 percent unfinished and those 2 are the tough nuts to crack). more or less we can traced what happened at genome to transcriptome level if we want. technically doable.
but in recent years, its discovered that many disease are actually epigenetic related, nothing got to do with mutation at the genome. it has more got to do with acetylation, phosphorylation, methylation of histones groups that is warping the chromosome. these epigenetic modification affects genes regulations - making of certain protein or suppression of it. that in terms give rises/maybe give a mechanism of cure to certain disease. epigenetic gives a plastic views of gene regulation that can accounts for environmental factors, like how the environments affects the acetylation, phosphorylation, methylation of histones proteins.
the unknown portion here to us is to know and understand the epigenetic pattern of these histone proteins, healthy vs disease. technically its difficult, eg need to find and developed specific antibodies to recognise those sites we want to study for enrichment.
this the summary
bow.
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