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The venom of the Brazilian wandering spider is infamous not only for causing intense pain, but also for triggering an unusual side effect in men: a prolonged, sometimes painful four-hour erection. This reaction is caused by a toxin in the venom that affects blood flow and nerve signaling. While the bite is medically dangerous and requires immediate treatment, the phenomenon has drawn scientific interest. Researchers are studying the venom’s mechanisms in hopes of developing new therapies for erectile dysfunction, showing how even the deadliest creatures can offer unexpected insights for medicine.