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The Monkeypox Thread. Time to cull these clowns!
- Thread starter kaninabuchaojibye
- Start date
Will Sharon Au get it????
If she open her legs for blackie lanjiao in France then high chances she gets infected.
She better cut off her cheebye in advance and stitch up for her own safety.
I can tell she's quite an itchy slut.
What about masks? Must wear or not?I suggest kiasi Sinkies wear disposable plastic gloves when they're out and about. Be responsible and help protect yourselves and your family!
Better wear triple layer mask starting tomorrow!
No need unless you copulate with gays.
That sounds logical. I am not scared of covid because I am boostered. Worried about this new health threat. Better don't monkey around with this monkey disease.
This thing is airborne right? Droplets?
Also need to carry a stick, in case those effeminate guys come too close, can whack them away!Airborne
Beware of crowded places especially places where lots of AMDKs
Are these people CONvid vaccinated?
Our beloved SPGs will be safe if they refuse backdoor sex with AMDKs.!
Monkeypox cases among gay, bisexual men reported in Portugal, Britain
May 19, 2022 — 5.31amBy Maria Cheng and Barry Hatton
Lisbon: Portuguese health authorities confirmed five cases of monkeypox in young men, and Britain announced another two, marking an unusual outbreak in Europe of a disease typically limited to Africa.
Portugal’s General Directorate for Health said it was also investigating 15 suspected cases and that all were identified this month in the area around the capital, Lisbon.
Monkeypox virions obtained from a sample of human skin associated with the 2003 prairie dog outbreak.APnone
All the Portuguese cases involve men, most of them young, authorities said, on Wednesday, Portugal time. They have skin lesions and were reported to be in stable condition. Authorities did not say if the men had a history of travel to Africa or any links with recent cases in Britain or elsewhere.
British health authorities said on Wednesday they had identified two new cases of monkeypox, one in London and another in south-east England. They said neither case had previously travelled to Africa and that it was possible they were infected in Britain. The cases had no known links to other previously confirmed patients, suggesting there may be multiple chains of monkeypox transmission already happening in the country.
Dr Susan Hopkins, chief medical adviser of Britain’s Health Security Agency, said the latest cases, alongside the other infections reported in Europe, “confirms our initial concerns that there could be spread of monkeypox within our communities”.
The agency said recent cases had been seen “predominantly in gay, bisexual or men who have sex with men”, although it noted it was unclear how exactly people had been infected.
Monkeypox has not previously been documented to have spread through sex, but can be transmitted through close contact with infected people, their clothing or bedsheets.
Earlier this week the UK agency reported four cases of monkeypox they said had been spread among gay and bisexual men in London. The agency said the risk to the general population “remains low”.
Health authorities in Spain’s central Madrid region said late on Wednesday that they were assessing 23 possible cases of monkeypox. They noted that all of the suspected cases are young men and that the majority of them had sex with other men.
The disease belongs to a family of viruses that includes smallpox. Most people recover from monkeypox within weeks, but the WHO said that the disease is fatal for up to one in ten people.
Sporadic cases of monkeypox have been seen previously in countries including Britain and the US, but nearly all have been in people who were likely infected during their travels in Africa.
Dr Ibrahim Soce Fall, the World Health Organisation’s assistant director-general for emergency response, said the spread of monkeypox in the UK needed to be investigated to understand how the disease was being transmitted among men who have sex with other men.
Fall said that health officials still need a better understanding of how monkeypox spreads in general, even in the countries where it is endemic.
He noted that while there were more than 6000 reported cases in Congo and about 3000 cases in Nigeria last year, there are still “so many unknowns in terms of the dynamics of transmission.”
Britain previously reported three earlier cases of monkeypox, two involving people who lived in the same household and the third someone who had travelled to Nigeria, where the disease occurs frequently in animals.
The virus has typically spread to people from infected animals like rodents, although human-to-human transmission has been known to occur.
Some British experts said it was soon to conclude that monkeypox had spread through sexual contact, although the outbreak there suggested that possibility.
“The recent cases suggest a potentially novel means of spread,” Neil Mabbott, a disease expert at the University of Edinburgh, said, adding that related viruses were known to spread via sex.
Keith Neal, an infectious diseases expert at the University of Nottingham, said the transmission might not have occurred through sexual activity but just “the close contact associated with sexual intercourse.”
Monkeypox typically causes fever, chills, a rash and lesions on the face or genitals resembling those caused by smallpox. A vaccine developed against smallpox has been approved for monkeypox, and several anti-virals also appear to be effective.
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TLDR version : Diagnosis of Imported Monkeypox, Israel, 2018 https://www.ncbi.nlm.nih.go... : " The patient was therefore hospitalized and administered oral doxycycline. His condition improved, and the next day he was discharged with doxycycline and instructions to remain isolated at home."
But but.... fear not Pfizer & CAQ will quickly have new vaccines for you............ esp those immunity compromised boostered 'tester' lol........... HUAT AH ~~ !
Diagnosis of Imported Monkeypox, Israel, 2018
We report a case of monkeypox in a man who returned from Nigeria to Israel in 2018. Virus was detected in pustule swabs by transmission electron microscopy and PCR and confirmed by immunofluorescence assay, tissue culture, and ELISA. The West Africa monkeypox outbreak calls for increased awareness by public health authorities worldwide.
Keywords: Monkeypox, outbreak, monkeypox virus, orthopoxvirus, transmission electron microscopy, zoonoses, disease outbreaks, viruses, Israel, West Africa
Monkeypox is a zoonotic disease caused by monkeypox virus, an orthopoxvirus closely related to variola virus, the causative agent of smallpox. Human cases were first described in 1970; in subsequent decades, sporadic outbreaks were reported in Africa. Mortality rates are 1%–10% (1,2). The 2 clades, Congo-Basin and West African, each cause disease; the West African clade is considered to be less virulent and is associated with a lower mortality rate (3). Nevertheless, this clade is responsible for the largest documented monkeypox outbreak in West Africa (132 confirmed cases in Nigeria) (4). Human infection with monkeypox occurred in the United States in 2003, when imported animals from Africa infected pet prairie dogs (5). In September 2018 in the United Kingdom, 2 imported cases of monkeypox, were detected in persons from Nigeria (6); one of these cases caused nosocomial infection of a healthcare worker (HCW). We report a case of monkeypox in Israel.Go to:
The Study
On October 4, 2018, a 38-year-old man sought care for generalized rash and fever at the Department of Emergency Medicine at Shaare-Zedek Medical Center, Jerusalem, Israel. This Israel resident had returned from Port Harcourt, Rivers State, Nigeria, where he had worked a desk job for the previous 10 years. On September 17, during his last trip to Nigeria, he had disposed of 2 rodent carcasses at his residence. He returned to Israel on September 23 and on September 29 noticed 2 itchy lesions on his penis shaft. The next day, he had fever (38.8°C) and chills and started self-medicating with nonsteroidal antiinflammatories and oral penicillin. On October 1, an erythematous rash appeared first on his face and later on his trunk and extremities.Examination at Shaare-Zedek Medical Center on October 4 revealed that the patient was febrile and had a nonblanching maculopapular rash on his face (Figure 1, panel A), neck, trunk, and lower and upper extremities; several lesions on his palms and soles; 2 ulcers with an erythematous base on his penis shaft; and bilateral enlarged and tender lymph nodes in his groin. Blood test results indicated moderate thrombocytopenia (98,000 platelets/μL) and mild hepatitis. One lesion on the posterior aspect of his left arm (Figure 1, panel B) was suspected to be an eschar, raising the possibility of rickettsialpox. The patient was therefore hospitalized and administered oral doxycycline. His condition improved, and the next day he was discharged with doxycycline and instructions to remain isolated at home.
[IMG alt="An external file that holds a picture, illustration, etc.
Object name is 19-0076-F1.jpg"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478227/bin/19-0076-F1.jpg[/IMG]
Figure 1
Dermal manifestations of monkeypox on patient in Israel, 2018. Maculopapular rash was apparent on the face (A) and body on the day of hospital admission. A lesion on the left proximal extremity (B) was suspected to be a rickettsial eschar. After 3 days, the rash changed into vesicles and pustules on the face (C) and body (D). Skin resolution was apparent 13 days after admission; pustules and vesicles crusted and were shed (E, F). G) Timeline of disease progression.
At a follow-up visit 2 days later (October 7), he was afebrile. The rash was locally synchronous and had progressed from maculopapular to vesicular and pustular; some lesions displayed black umbilication and crusting (Figure 1, panels C, D). Oral examination revealed bilateral tonsillar enlargement and ulcers in the posterior pharynx. Serology results were positive for varicella IgG (past infection) and negative for Coxiella burnetii, Rickettsia conori, Rickettsia typhi, Brucella spp., Treponema pallidum, and antigen/antibody combination for HIV. Pustular samples were negative for herpes simplex virus by PCR. Because of the rash characteristics and the patient’s travel history, monkeypox was suspected.
Samples were sent to the Israel Institute for Biological Research, Ness-Ziona, Israel, and processed in Biosafety Level 3 laboratories. The pustule sample was processed for PCR analysis and transmission electron microscopy. Vero cells were infected for immunofluorescence assay and monitored for cytopathic effect. For transmission electron microscopy, particles were enriched by using a Beckman Airfuge (https://www.beckman.com) before negative staining with phosphotungstic acid.
The sample exhibited numerous brick-shaped particles, characteristic of orthopoxviruses. Particles were observed to be in clusters (up to 10 virions in each cluster) embedded in skin tissue and as single virions (Figure 2, panels A, B). Viral particle dimensions (± SD) were 281 ± 18 nm × 220 ± 17 nm (n = 24), in accordance with previously reported dimensions for monkeypox virus (5).
[IMG alt="An external file that holds a picture, illustration, etc.
Object name is 19-0076-F2.jpg"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478227/bin/19-0076-F2.jpg[/IMG]
Figure 2
Transmission electron microscopy and cell culture–based diagnosis of monkeypox in patient in Israel, 2018. Virus particles were detected in lesion samples as either virion aggregates (arrows) (A) or individual virions (B) with a typical brick shape. Infected Vero cells depicted typical cytopathic effect, exhibiting cell detachment and rounding. Scale bar in A indicates 0.2 μm; scale bar in B indicates 100 nm. C) Infected Vero cells depicting typical cytopathic effect: cell detachment and rounding. Original magnification ×10. D) Immunofluorescent staining of infected Vero cells: DNA (DAPI [4′,6-diamidino-2-phenylindole] stain) and monkeypox virus; viral factories are evident (arrows). Original magnification ×25.
PCR diagnosis was based on specific primers to discriminate between the West African (581 bp) and the Congo-Basin (832 bp) clades by product size (7). The PCR product size corresponded to that of the West African clade currently circulating in Nigeria (8). This finding was confirmed by high-throughput sequencing.
Within 24 hours of infection, cytopathic effect was observed in Vero cells, exhibiting typical monolayer separation and cell rounding (Figure 2, panel C). The result of immunofluorescence assay with a specific antibody against orthopoxviruses was positive; some cells exhibited viral factories, typical for orthopoxvirus infection (Figure 2, panel D) (9).
The patient was instructed to remain isolated in his residence until he had fully recovered. Days after he returned home, the pustules turned to scabs (0.3–0.8 mm in diameter) and were shed (Figure 1, panels E, F). Concomitant with recovery, antibodies against orthopoxvirus and a neutralizing antibody titer (50% plaque reduction neutralization test titer = 134) developed, comparable to those of smallpox-vaccinated humans (10). Of note, scabs collected from the patient during recovery, then homogenized and tested for monkeypox virus, contained viable viral loads of 105–107 PFU/scab.
All of the patient’s contacts in Israel (5 household members and 11 HCWs) were offered smallpox vaccination, but only 1 HCW agreed. All contacts were followed up for 21 days; no virus transmission was detected.
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Conclusions
Since the first documented case of human monkeypox in 1970, sporadic outbreaks have been reported, especially in the Congo Basin and West Africa. Contributing to the increased frequency of such occurrences were discontinued vaccination against smallpox, increased interaction with wildlife because of deforestation and population movement, consumption of bushmeat, and increased population density (11,12). Although most infections are acquired from wildlife, human-to-human transmission has been reported, as in the 1996–1997 outbreak in the Democratic Republic of the Congo (13) and the current outbreak in West Africa (8). The availability and speed of international transportation combined with the natural progression of the disease (long incubation and prodromal periods, up to 21 days combined) increase the risk for monkeypox spread from rural regions into urban areas and to countries outside Africa. Indeed, during September and October 2018, monkeypox was diagnosed in the United Kingdom and Israel (6,14).Thus far, all imported cases of monkeypox in humans (United States in 2003, United Kingdom and Israel in 2018) have involved the West African clade of the virus (3,6). After a similar incubation period (12 days), all patients had fever and chills, lymphadenopathy, and skin lesions (5,6). Although the patient in Israel had numerous vesiculopustules on his face and body, the patients involved in the US outbreak had substantially fewer (1–50) and reported a persistent cough, which the patient from Israel did not report. Of note, the first sign noted by the Israel and UK patients was groin lesions (6). Although past reports considered the Congo Basin clade to be more virulent (2,3,12), recent reports show that the West African clade can also cause disseminated disease and can be transmitted from human to human (4,8).
For this study, we used multiple diagnostic approaches. The virus was detected in pustule swab specimens by transmission electron microscopy and PCR within 3 hours of sample arrival and confirmed by immunofluorescence assay, tissue culture, and ELISA for orthopoxvirus antigens.
The very high virus titers contained by pustules and scabs, as demonstrated in this case, increase the risk for human-to-human transmission and environmental spread. To prevent further transmission, HCWs should implement safety practices and local authorities should map contacts and consider use of smallpox vaccines or antiviral drugs (14,15), according to risk assessment.
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Acknowledgment
https://www.channelnewsasia.com/world/belgian-monkeypox-outbreak-linked-fetish-festival-2697306
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