Sexually transmitted infections (STIs) are rebounding in developed countries after being firmly in retreat for decades. The consequences can be devastating. Syphilis, for example, causes more than 200,000 stillbirths and infant deaths worldwide annually, and years later can lead to blindness, dementia or paralysis. The resurgence is a result of multiple factors including inconsistent condom usage and the abuse of illicit recreational drugs. At the same time, some common STIs, such as gonorrhea and shigellosis, are becoming harder to treat due to antibiotic resistance. In the U.S., which has the highest rates of sexually transmitted disease in the developed world, the crisis is costing an estimated $16 billion annually in preventable health-care expenses.
Main Culprits
Breakdown of top-four curable STIs by incidence globally
Source: World Health Organization, 2018
1. How bad is the problem?
In the U.S., cases of chlamydia, gonorrhea, and syphilis -- three of the most common, treatable sexually transmitted diseases -- jumped by more than 200,000 in 2017 to almost 2.3 million, a record. With syphilis, the annual rate of reported cases in the U.S. has almost doubled in recent years, to 31.4 cases per 100,000 people in 2017 from 15.9 per 100,000 in 2012. The trend with syphilis has also been seen in such countries as France, Belgium, Ireland and the U.K. In Australia, reported cases of gonorrhea climbed 63 percent from 2012 to 2016, while they surged sixfold in France and almost fivefold in Denmark from 2007 to 2016.
Resurgent Bug
Syphilis incidence in the U.S. is the highest since 1994
Source: Centers for Disease Control and Prevention
2. What’s driving that rise?
It’s complicated. Take syphilis: While the bulk of the roughly 6 million cases occurring annually are in low- and middle-income countries, some of the largest annual increases are in high-income countries. In these countries, syphilis has spread from some high-risk groups, such as gay and bisexual men, to the wider community. In the U.S., rates of early-stage syphilis among women surged 156 percent from 2013 to 2017. The Centers for Disease Control and Prevention says that’s associated with a corresponding rise in sexualized drug use -- using methamphetamines or injection drugs, including heroin, to facilitate unprotected sex with multiple partners. Similarly in Europe, such practices, known as “party and play (PnP),” “chemsex” or “slamming,” have been shown to spur sex work and risky behavior, especially among men who have sex with men.
3. Are there other factors?
Yes. In the U.S., for example, the decline in AIDS mortality since the mid-1990s has been associated with a rebound in syphilis cases among men who have sex with men. More recently, the introduction of drugs to prevent HIV transmission -- called pre-exposure prophylaxis, or PrEP -- has shown great promise in reducing new infections among these men. It’s also been associated with less consistent use of condoms -- one of the best means of protection against other STIs. More routine STI screening tests among PrEP users has made it difficult to know whether previously unrecognized and untreated infections are now being diagnosed or if there has been an actual increase. More international travel and labor migration also mean that germs are spreading faster and wider.
A 1940s Work Projects Administration poster promoting the eradication of syphilis.
Source: Library of Congress
4. What are the consequences?
Each infectious agent presents its own particular dangers. For example, up to 40 percent of pregnancies with untreated syphilis result in miscarriage, stillbirth or early infant death. The surviving babies may suffer from abnormalities including skeletal defects, hearing impairment and meningitis, which can cause developmental delays and seizures. Reported cases of syphilis passed from a mother to her baby have more than doubled in the U.S. since 2013, reaching a 20-year high of 918 in 2017. Florida, California, Arizona, Texas and Louisiana accounted for 70 percent of cases. With chlamydia, 80 percent of infections are asymptomatic, yet even then it can be spread via sex. The infection is particularly serious for women. If untreated it may move to the upper reproductive tract, resulting in pelvic inflammatory disease. That can lead to ectopic pregnancy, chronic pain and infertility. Newborns may get pneumonia if they are infected in the uterus. Men with untreated chlamydia may develop arthritis.
5. How serious is drug-resistant gonorrhea?
Very. The bacterium has evolved to thwart multiple antibiotics, leading to four reported cases of extensively drug-resistant disease in the U.K. and two in Australia. While the bacterium is broadly susceptible to some newer antibiotics, these appear to be less effective at clearing the infection from the throat. Germs in the throat can spread surreptitiously via kissing, making them harder to stop. A key concern is that ceftriaxone, a backbone of treatment globally, is losing its potency, hastening the threat of untreatable gonorrhea. When the disease isn’t treated, it can cause infertility in both women and men, and potentially lead to a lethal bloodstream infection.
6. What can be done?
Experience has shown that encouraging condom use isn’t sufficient to curb infections. New tools and therapeutic agents, such as antiviral and antibiotic drugs, are needed. Vaccines, which have significantly reduced cases of human papillomavirus (HPV) and hepatitis B cases, could be an important defense. Research into vaccines against herpes and HIV is advanced, while those for chlamydia, gonorrhea, syphilis and trichomoniasis, another common STI, are in earlier stages of development.
7. What about the rest of the world?
Most of the more than 1 million people who catch a sexually transmitted infection each day are in low- and middle-income countries. Broadly, STIs are a barometer of access to health care: The worst rates occur in groups least likely to be tested and treated. The World Health Organization recognizes female sex workers, people who inject drugs, men who have sex with men, and transgender women as being most vulnerable. Faster and more-reliable testing at the point of care would make it easier to detect and treat infections earlier, especially in developing countries and remote areas.
Main Culprits
Breakdown of top-four curable STIs by incidence globally
Source: World Health Organization, 2018
1. How bad is the problem?
In the U.S., cases of chlamydia, gonorrhea, and syphilis -- three of the most common, treatable sexually transmitted diseases -- jumped by more than 200,000 in 2017 to almost 2.3 million, a record. With syphilis, the annual rate of reported cases in the U.S. has almost doubled in recent years, to 31.4 cases per 100,000 people in 2017 from 15.9 per 100,000 in 2012. The trend with syphilis has also been seen in such countries as France, Belgium, Ireland and the U.K. In Australia, reported cases of gonorrhea climbed 63 percent from 2012 to 2016, while they surged sixfold in France and almost fivefold in Denmark from 2007 to 2016.
Resurgent Bug
Syphilis incidence in the U.S. is the highest since 1994
Source: Centers for Disease Control and Prevention
2. What’s driving that rise?
It’s complicated. Take syphilis: While the bulk of the roughly 6 million cases occurring annually are in low- and middle-income countries, some of the largest annual increases are in high-income countries. In these countries, syphilis has spread from some high-risk groups, such as gay and bisexual men, to the wider community. In the U.S., rates of early-stage syphilis among women surged 156 percent from 2013 to 2017. The Centers for Disease Control and Prevention says that’s associated with a corresponding rise in sexualized drug use -- using methamphetamines or injection drugs, including heroin, to facilitate unprotected sex with multiple partners. Similarly in Europe, such practices, known as “party and play (PnP),” “chemsex” or “slamming,” have been shown to spur sex work and risky behavior, especially among men who have sex with men.
3. Are there other factors?
Yes. In the U.S., for example, the decline in AIDS mortality since the mid-1990s has been associated with a rebound in syphilis cases among men who have sex with men. More recently, the introduction of drugs to prevent HIV transmission -- called pre-exposure prophylaxis, or PrEP -- has shown great promise in reducing new infections among these men. It’s also been associated with less consistent use of condoms -- one of the best means of protection against other STIs. More routine STI screening tests among PrEP users has made it difficult to know whether previously unrecognized and untreated infections are now being diagnosed or if there has been an actual increase. More international travel and labor migration also mean that germs are spreading faster and wider.
A 1940s Work Projects Administration poster promoting the eradication of syphilis.
Source: Library of Congress
4. What are the consequences?
Each infectious agent presents its own particular dangers. For example, up to 40 percent of pregnancies with untreated syphilis result in miscarriage, stillbirth or early infant death. The surviving babies may suffer from abnormalities including skeletal defects, hearing impairment and meningitis, which can cause developmental delays and seizures. Reported cases of syphilis passed from a mother to her baby have more than doubled in the U.S. since 2013, reaching a 20-year high of 918 in 2017. Florida, California, Arizona, Texas and Louisiana accounted for 70 percent of cases. With chlamydia, 80 percent of infections are asymptomatic, yet even then it can be spread via sex. The infection is particularly serious for women. If untreated it may move to the upper reproductive tract, resulting in pelvic inflammatory disease. That can lead to ectopic pregnancy, chronic pain and infertility. Newborns may get pneumonia if they are infected in the uterus. Men with untreated chlamydia may develop arthritis.
5. How serious is drug-resistant gonorrhea?
Very. The bacterium has evolved to thwart multiple antibiotics, leading to four reported cases of extensively drug-resistant disease in the U.K. and two in Australia. While the bacterium is broadly susceptible to some newer antibiotics, these appear to be less effective at clearing the infection from the throat. Germs in the throat can spread surreptitiously via kissing, making them harder to stop. A key concern is that ceftriaxone, a backbone of treatment globally, is losing its potency, hastening the threat of untreatable gonorrhea. When the disease isn’t treated, it can cause infertility in both women and men, and potentially lead to a lethal bloodstream infection.
6. What can be done?
Experience has shown that encouraging condom use isn’t sufficient to curb infections. New tools and therapeutic agents, such as antiviral and antibiotic drugs, are needed. Vaccines, which have significantly reduced cases of human papillomavirus (HPV) and hepatitis B cases, could be an important defense. Research into vaccines against herpes and HIV is advanced, while those for chlamydia, gonorrhea, syphilis and trichomoniasis, another common STI, are in earlier stages of development.
7. What about the rest of the world?
Most of the more than 1 million people who catch a sexually transmitted infection each day are in low- and middle-income countries. Broadly, STIs are a barometer of access to health care: The worst rates occur in groups least likely to be tested and treated. The World Health Organization recognizes female sex workers, people who inject drugs, men who have sex with men, and transgender women as being most vulnerable. Faster and more-reliable testing at the point of care would make it easier to detect and treat infections earlier, especially in developing countries and remote areas.
