Pfizer to ask FDA to authorise booster dose of COVID-19 vaccine as Delta variant spreads
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Pfizer chief scientific officer Mikael Dolsten said the recently reported dip in the vaccine's effectiveness in Israel was mostly due to infections in people who had been vaccinated in January or February. The country's health ministry said vaccine effectiveness in preventing both infection and symptomatic disease fell to 64 per cent in June.
"The Pfizer vaccine is highly active against the Delta variant," Dolsten said in an interview. But after six months, he said "there likely is the risk of reinfection as antibodies, as predicted, wane".
Pfizer did not release the full set of Israeli data on Thursday, but said it would be published soon.
He stressed that data from Israel and Britain suggests that even with waning antibody levels, the vaccine remains around 95 per cent effective against severe disease.
The vaccine, developed with German partner BioNTech, showed 95 per cent efficacy in preventing symptomatic COVID-19 in a clinical trial the companies ran last year.
Dolsten said that early data from the company's own studies shows that a third booster dose generates antibody levels that are five to 10-fold higher than after the second dose, suggesting that a third dose will offer promising protection.
He said that multiple countries in Europe and elsewhere have already approached Pfizer to discuss booster doses, and that some may begin administering them before a potential US authorisation.
Dolsten said he believes that booster shots are particularly important in older age groups.
Because boosters will drive increasing demand for vaccines as much of the world is still unvaccinated, Dolsten said Pfizer is looking at ways to boost production.
Pfizer is already targeting production of 3 billion doses this year and 4 billion doses next year. Dolsten declined to give a forecast of exactly how many more doses the company could add, but said "we can step up billion after billion in '22".
Pfizer CEO Albert Bourla has said people will likely need a booster dose of the company’s vaccine every 12 months - similar to an annual flu shot. But some scientists question when, or whether, such shots will be needed.
www.channelnewsasia.com
NEW YORK: Pfizer plans to ask US regulators to authorise a booster dose of its COVID-19 vaccine within the next month, the drugmaker's top scientist said on Thursday (Jul 8), based on evidence of greater risk of reinfection six months after inoculation and due to the spread of the highly contagious Delta variant. Pfizer chief scientific officer Mikael Dolsten said the recently reported dip in the vaccine's effectiveness in Israel was mostly due to infections in people who had been vaccinated in January or February. The country's health ministry said vaccine effectiveness in preventing both infection and symptomatic disease fell to 64 per cent in June.
"The Pfizer vaccine is highly active against the Delta variant," Dolsten said in an interview. But after six months, he said "there likely is the risk of reinfection as antibodies, as predicted, wane".
Pfizer did not release the full set of Israeli data on Thursday, but said it would be published soon.
He stressed that data from Israel and Britain suggests that even with waning antibody levels, the vaccine remains around 95 per cent effective against severe disease.
The vaccine, developed with German partner BioNTech, showed 95 per cent efficacy in preventing symptomatic COVID-19 in a clinical trial the companies ran last year.
Dolsten said that early data from the company's own studies shows that a third booster dose generates antibody levels that are five to 10-fold higher than after the second dose, suggesting that a third dose will offer promising protection.
He said that multiple countries in Europe and elsewhere have already approached Pfizer to discuss booster doses, and that some may begin administering them before a potential US authorisation.
Dolsten said he believes that booster shots are particularly important in older age groups.
Because boosters will drive increasing demand for vaccines as much of the world is still unvaccinated, Dolsten said Pfizer is looking at ways to boost production.
Pfizer is already targeting production of 3 billion doses this year and 4 billion doses next year. Dolsten declined to give a forecast of exactly how many more doses the company could add, but said "we can step up billion after billion in '22".
Pfizer CEO Albert Bourla has said people will likely need a booster dose of the company’s vaccine every 12 months - similar to an annual flu shot. But some scientists question when, or whether, such shots will be needed.
