[Medical] - AstraZeneca's covid vaccine's 90% effective 'half-1st-dose' method was a 'lucky accident'! KNN!!!

[UltimaOnline]

On Monday, AstraZeneca and Oxford released details about the first 131 volunteers to get COVID-19 in late-stage trials in the United Kingdom and Brazil. All of the volunteers got two doses about a month apart, but in some cases the first dose was only at half strength.

Surprisingly, the vaccine combination in which the first dose was only at half strength was 90% effective at preventing COVID-19 in the trial. In contrast, the combination of two, full-dose shots led to just 62% efficacy.

Why would that be?

No one knows. The researchers speculated that the lower first dose did a better job of mimicking the experience of an infection, promoting a stronger immune response. But other factors, like the size and makeup of the groups that got different doses, may also be at play.

Why did the researchers test two different doses?

It was a lucky mistake. Researchers in Britain had been meaning to give volunteers the initial dose at full strength, but they made a miscalculation and accidentally gave it at half strength, Reuters reported. After discovering the error, the researchers gave each affected participant the full strength booster shot as planned about a month later.

https://sg.yahoo.com/news/know-astrazenecas-head-scratching-vaccine-193851647.html

 

[eatshitndie]

may be they should try with 69% of both dozes. like that trial and error doesn’t give me the confidence. the mrna vaccine is way more consistent and reliable.

 

[tobelightlight]

 

[eatshitndie]

many questions on astrazeneca and oxford university vaccine results came up today. how fucked up can researchers in astrazeneca and oxfuck u. be? this is truly a fucked up outfit who can't seem to pinpoint the issues and results correctly. the "goldilocks" comment by an oxfuck u. scientist truly epitomizes the fuck up - it is truly a "trial and error" approach to guessing the "right amount".

https://www.sfgate.com/news/article/AstraZeneca-manufacturing-error-clouds-vaccine-15754874.php

AstraZeneca manufacturing error clouds vaccine study results
DANICA KIRKA, Associated Press
Nov. 25, 2020

"In a statement Wednesday, Oxford University said some of the vials used in the trial didn’t have the right concentration of vaccine so some volunteers got a half dose. The university said that it discussed the problem with regulators, and agreed to complete the late stage trial with two groups. The manufacturing problem has been corrected, according to the statement.

WHAT ABOUT THE RESULTS THEMSELVES?

Experts say the relatively small number of people in the low dose group makes it difficult to know if the effectiveness seen in the group is real or a statistical quirk. Some 2,741 people received a half dose of the vaccine followed by a full dose, AstraZeneca said. A total of 8,895 people received two full doses.

Another factor: none of the people in the low-dose group were over 55 years old. Younger people tend to mount a stronger immune response than older people, so it could be that the youth of the participants in the low-dose group is why it looked more effective, not the size of the dose.

Another point of confusion comes from a decision to pool results from two groups of participants who received different dosing levels to reach an average 70% effectiveness, said David Salisbury, and associate fellow of the global health program at the Chatham House think tank.

“You’ve taken two studies for which different doses were used and come up with a composite that doesn’t represent either of the doses,″ he said of the figure. “I think many people are having trouble with that.″

WHY WOULD A SMALLER FIRST DOSE BE MORE EFFECTIVE?

Oxford researchers say they aren’t certain and they are working to uncover the reason.

Sarah Gilbert, one of the Oxford scientists leading the research, said the answer is probably related to providing exactly the right amount of vaccine to trigger the best immune response.

“It’s the Goldilocks amount that you want, I think, not too little and not too much. Too much could give you a poor quality response as well,’’ she said. “So you want just the right amount and it’s a bit hit and miss when you’re trying to go quickly to get that perfect first time.”

 

[redbull313]

many questions on astrazeneca and oxford university vaccine results came up today. how fucked up can researchers in astrazeneca and oxfuck u. be? this is truly a fucked up outfit who can't seem to pinpoint the issues and results correctly. the "goldilocks" comment by an oxfuck u. scientist truly epitomizes the fuck up - it is truly a "trial and error" approach to guessing the "right amount".

https://www.sfgate.com/news/article/AstraZeneca-manufacturing-error-clouds-vaccine-15754874.php

AstraZeneca manufacturing error clouds vaccine study results
DANICA KIRKA, Associated Press
Nov. 25, 2020

"In a statement Wednesday, Oxford University said some of the vials used in the trial didn’t have the right concentration of vaccine so some volunteers got a half dose. The university said that it discussed the problem with regulators, and agreed to complete the late stage trial with two groups. The manufacturing problem has been corrected, according to the statement.

WHAT ABOUT THE RESULTS THEMSELVES?

Experts say the relatively small number of people in the low dose group makes it difficult to know if the effectiveness seen in the group is real or a statistical quirk. Some 2,741 people received a half dose of the vaccine followed by a full dose, AstraZeneca said. A total of 8,895 people received two full doses.

Another factor: none of the people in the low-dose group were over 55 years old. Younger people tend to mount a stronger immune response than older people, so it could be that the youth of the participants in the low-dose group is why it looked more effective, not the size of the dose.

Another point of confusion comes from a decision to pool results from two groups of participants who received different dosing levels to reach an average 70% effectiveness, said David Salisbury, and associate fellow of the global health program at the Chatham House think tank.

“You’ve taken two studies for which different doses were used and come up with a composite that doesn’t represent either of the doses,″ he said of the figure. “I think many people are having trouble with that.″

WHY WOULD A SMALLER FIRST DOSE BE MORE EFFECTIVE?

Oxford researchers say they aren’t certain and they are working to uncover the reason.

Sarah Gilbert, one of the Oxford scientists leading the research, said the answer is probably related to providing exactly the right amount of vaccine to trigger the best immune response.

“It’s the Goldilocks amount that you want, I think, not too little and not too much. Too much could give you a poor quality response as well,’’ she said. “So you want just the right amount and it’s a bit hit and miss when you’re trying to go quickly to get that perfect first time.”

shooo tiong shooo go back to china shooo!

 

[tobelightlight]

 

[syed putra]

View attachment 96953

Vitamin D. That was what one Dr recommended.

 

[redbull313]

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shooo tiong shooo go back to CHina shoooo!