Serious Huat Ah! Hurry spread ZIKA all over SG53 can prevent PAP brain damage

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https://www.rt.com/news/402122-mutant-zika-virus-cancer-treatment/


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Mutant Zika virus could be new secret weapon in fighting brain cancer – researchers
Published time: 5 Sep, 2017 23:31
Mutant Zika virus could be new secret weapon in fighting brain cancer – researchers
© Mike Segar / Reuters
59
Medical researchers in the US have weaponized a mutated form of the Zika virus in the hopes of defeating a common, tenacious and highly aggressive form of brain cancer with some highly promising initial results.
“We showed that Zika virus can kill the kind of glioblastoma [brain cancer] cells that tend to be resistant to current treatments and lead to death,” said Michael S. Diamond, Professor of Medicine at Washington University School of Medicine and the study’s co-senior author.

Glioblastoma is the most common form of brain cancer and is both highly lethal and highly resistant to surgery, radiation, and chemotherapy treatments, with a median survival rate of less than two years following diagnosis. Its self-regenerating cells that spread out from the initial site of the tumor are what make it so hard to kill.


In a paper published in the Journal of Experimental Medicine on Tuesday, the joint team from Washington University School of Medicine and the University of California San Diego School of Medicine unveiled its results from tests conducted on adult mice and donated adult human brain cells in the laboratory.

In the tests, conducted on adult mice, the modified Zika virus preferentially infected and killed the cancer stem cells as opposed to the other cells within the tumor or the healthy cells within the test subjects’ brains, unlike the West Nile virus, which is indiscriminate in which cells it attacks.

The weaponized Zika and a saltwater placebo were injected into 18 and 15 mice respectively. The tumors in the Zika-infected mice shrank dramatically and they survived "significantly longer than the ones given saltwater."


While the Zika virus is incredibly damaging to infants in the womb, leading to microcephaly and other brain malformations in some babies, its effects on adult humans are generally far less severe, with cases of meningoencephalitis rare.

Infant brains have far more stem cells, specifically neuroprogenitor cells, than adult brains, which may explain why the treatment is so promising for adult cancer patients.

Approximately 12,000 people are diagnosed with glioblastoma in the US each year, reports the Washington University of Medicine in St. Louis, among them is US Senator John McCain, who was diagnosed in July.


“We’re going to introduce additional mutations to sensitize the virus even more to the innate immune response and prevent the infection from spreading,” Diamond, a professor of molecular microbiology, added.

“Once we add a few more changes, I think it’s going to be impossible for the virus to overcome them and cause disease.”

A controlled infection with a modified version of Zika in combination with chemotherapy-radiation could one day be used in tandem to defeat this particularly aggressive form of cancer.

“We see Zika one day being used in combination with current therapies to eradicate the whole tumor,” said co-author Milan Chheda, an assistant professor of medicine and neurology, as cited by The Washington University School of Medicine.

 

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ZIKA which makes your brains SMALLER is used to shrink Brain Cancer!

KNN! No Joke!

http://www.bbc.com/news/health-41146628


Zika virus used to treat aggressive brain cancer
By Michelle Roberts Health editor, BBC News online

5 September 2017
From the section Health

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Image copyright Getty Images

A harmful virus that can cause devastating brain damage in babies could offer up a surprising new treatment for adult brain cancer, according to US scientists.

Until now, Zika has been seen only as a global health threat - not a remedy.

But latest research shows the virus can selectively infect and kill hard-to-treat cancerous cells in adult brains.

Zika injections shrank aggressive tumours in fully grown mice, yet left other brain cells unscathed.

Human trials are still a way off, but experts believe Zika virus could potentially be injected into the brain at the same time as surgery to remove life-threatening tumours, the Journal of Experimental Medicine reports.

The Zika treatment appears to work on human cell samples in the lab.

There are many different types of brain cancer. Glioblastomas are the most common in adults and one of the trickiest to treat.

They are fast growing and diffuse, meaning they spread through the brain, making it difficult to see where the tumour ends and the healthy tissue begins.

Radiotherapy, chemotherapy and surgery may not be enough to remove these invasive cancers.

But the latest research, in living mice and donated human brain tissue samples, shows Zika therapy can kill cells that tend to be resistant to current treatments.

It is thought that these glioblastoma stem cells continue to grow and divide, producing new tumour cells even after aggressive medical treatment.

Different, healthy stem cells are found in abundance in baby brains, which probably explains why regular Zika can be so damaging to infants, say the researchers.

Adult brains, however, have very few stem cells. This means Zika treatment should destroy only the cancer-causing brain stem cells without causing much collateral damage.

As an extra safety precaution, the team, from Washington University School of Medicine and the University of California San Diego School of Medicine, have already begun modifying the virus to make it more tame than regular Zika.

Researcher Dr Michael Diamond said: "Once we add a few more changes, I think it's going to be impossible for the virus to overcome them and cause disease.

"It looks like there's a silver lining to Zika. This virus that targets cells that are very important for brain growth in babies, we could use that now to target growing tumours."

He hopes to begin human trials within 18 months.

Using viruses to fight cancer is not a new idea, but using Zika as the weapon of choice is.

UK scientists at the University of Cambridge are beginning similar trials with Zika.

Dr Catherine Pickworth, from Cancer Research UK, said: "This promising research shows that a modified version of the Zika virus can attack brain tumour cells in the lab.

"This could one day lead to new treatments for this particularly hard to treat type of cancer."
Zika

Zika is a virus people can catch if they are bitten by an infected mosquito
Most people will have few or no symptoms, but the disease can pose a serious threat to babies in the womb
Affected infants have been born with abnormally small heads and underdeveloped brains - a condition known as microcephaly
The infection has been linked to severe birth defects in almost 30 countries
Although Zika is no longer "an international medical emergency", the World Health Organization says it is closely monitoring the infection

 

[halsey02]

Singaporeans 70% brains had already shrunk, by voting for the PAP since 1959...scientists must come here & do a research.