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上海男子被感染7天后出院：康复很幸运，愿捐血清救人
新京报
02-14 15:01新京报社官方帐号
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新京报讯（记者 刘浩南 俞金旻 靳晴）今日（2月14日），新京报记者从上海市卫健委获悉，今日有28例新冠肺炎确诊病例治愈出院，出院病例累计90例，其中6个康复者愿意捐献血浆帮助治疗及研究。捐献者刘先生告诉新京报记者，自己能康复非常幸运，很愿意捐献血清，希望自己的血清能帮助治疗危重病人。
康复者刘先生称愿意捐献血清帮助治疗。新京报记者 俞金旻 摄
今日，康复者刘先生戴着口罩，从上海市公共卫生临床中心出院，向新京报记者详述自己感染及康复的过程。据刘先生介绍，他在过年期间曾到家乡东北拜访一位老师，这位老师的儿子于2月6日被确诊新冠肺炎。刘先生获悉后主动到医院排查，于2月7日被确诊，并入院接受治疗。刘先生接受7天治疗后，经专家组评估，认为其符合确诊病例解除隔离和出院标准。
刘先生告诉新京报记者，他到老师家中拜访时间大约为20分钟，当时老师的儿子已经离家，未直接接触。老师的儿子只在父母家中住过一晚，被确诊前无相关症状。
据刘先生称，老师的儿子曾在北京参加过一个会议，事后有多名参会者被确诊。刘先生坦承，被确诊前未发现症状，拜访完老师后获悉相关情况，心里非常忐忑，于是决定主动到医院排查。
“治疗还是非常顺利的，很幸运我康复了。康复之后，我的血清可能对其他患者的治疗有一定帮助，所以我愿意捐献我的血清。”刘先生告诉记者。
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上海又有28例痊愈患者出院，有治愈者主动提出捐献血浆
2020-02-14 17:02 北晚新视觉综合 TF019
上海14日又有28名患者治愈出院，这是上海近期出院的患者中人数最多的一批。截至记者发稿前，上海累计有90例患者痊愈。另据上海市卫健委最新通报：2月14日0—12时，上海市无新增确诊病例。
资料图 新华社记者 晋美多吉 摄
对于大众关注的康复者血浆问题，国家卫生健康委专家组成员、上海市公共卫生临床中心党委书记卢洪洲表示，14日出院患者中有6名愿意捐献血浆。之后将视患者身体状况，在两到四周内进行血液样本的采集。
“目前来看，血浆疗法对患者，尤其是重症患者或许是有价值的。今天的这批出院的患者主动提出可以捐血，令我非常感动。”他认为，痊愈患者献血救人的做法，将给治疗带来积极作用。
据报道，2月8日，以新冠肺炎诊疗方案(试行第五版)为指南，首期在武汉江夏区第一人民医院开展了3名危重患者的新冠特免血浆治疗，目前连同后续医院治疗的危重病人超过了10人。临床反映，患者接受治疗12至24小时后，实验室检测主要炎症指标明显下降，淋巴细胞比例上升，血氧饱和度、病毒载量等重点指标全面向好，临床体征和症状明显好转。
卢洪洲介绍，上海已有一例患者准备使用恢复期患者的血浆，“我期待着血浆疗法能够对重症患者尤其是危重症患者起到一定作用”。
此次出院患者刘先生表示，“从住院到出院，我只用了7天，感谢所有医务人员的关心和照顾。”在得知治愈者的血浆能够对危重患者起作用后，刘先生立即报名，希望献出自己的力量，用于救治其他患者或帮助科学研究。
14日早晨从日内瓦参会回国的沈银忠是上海市公共卫生临床中心医务部主任，这次也作为中国内地唯一专家参与了制定WHO新型冠状病毒感染临床管理指南。
他向记者介绍，“我们可以理解公众对血浆置换术的关心和期待，但是这种方法并不稀奇，之前很多传染病都在用，我们之前早就考虑过这种方法。”沈银忠说，血浆置换对新冠肺炎的治疗效果，还有待后续进一步观察，“可能会有一定的效果，但不要寄希望于使用某种方法就可以一下子摆平新冠肺炎，还是要以综合治疗为原则。”
延伸阅读：
2月13日晚，武汉金银潭医院院长张定宇对外表示，金银潭医院正在开展康复病人的恢复期血浆输注，目前也显示出一些初步效果，因为康复期患者体内有大量综合抗体来对抗病毒。
资料图 新华社记者 晋美多吉 摄
这也是新冠肺炎疫情爆发以来，首次有一线医疗专家确认了“血清疗法”用于临床救治。
实际上，在国家卫健委发布试行第四版的《新型冠状病毒感染的肺炎诊疗方案》中就已经正式提出，对重型、危重型病人治疗措施“可采用恢复期血浆治疗”。
使用康复期患者的血浆输注进行临床治疗的思路，在抗击SARS疫情时期实际上就已有之。
钟南山院士就曾在当时提出过用康复者血清治疗SARS患者的建议，天坛生物也曾研制SARS抗病毒血清。中国香港和台湾地区的一些医院也曾对SARS重病患开展过血清疗法，并取得了不错的疗效。
在疫情爆发后医药界苦苦寻找治疗新冠病毒肺炎药物时，就有多位行业专家曾对界面新闻记者提出，使用康复期患者的血浆输注治疗是一个选择。
简单来说，目前对于新冠病毒肺炎没有特效药，而患者在被病毒感染后，自身免疫系统会针对新冠病毒出现免疫应答，产生相应的特异性抗体，当这些新冠病毒特异性抗体具备足够规模时，就有可能战胜体内的新冠病毒。
而康复患者体内血液中往往就存在着足够规模的新冠病毒特异性抗体，通过对他们的血液抽取，对其血清进行一定的处理，便可以通过输血的方式把康复者血液中的抗体给到临床病人，帮助患者自身免疫系统对抗新冠病毒。
大众所关切的疫苗，实际上以传统的灭活疫苗为例，也是将被杀死病毒以疫苗方式接种人体，随后由免疫系统产生相应抗体，相比之下使用康复患者的血清治疗则更加直接。
“中国生物”也在2月13日晚宣布，已完成对部分康复者血浆的采集工作，开展新冠病毒特免血浆制品和特免球蛋白的制备。经过严格的血液生物安全性检测，病毒灭活，抗病毒活性检测等，已成功制备出用于临床治疗的特免血浆。
2月8日，以新型冠状病毒感染的肺炎诊疗方案（试行第五版）为指南，首期在江夏区第一人民医院开展了3名危重患者的新冠特免血浆治疗，目前连同后续医院治疗的危重病人超过了10人。临床反映，患者接受治疗12至24小时后，实验室检测主要炎症指标明显下降，淋巴细胞比例上升，血氧饱和度、病毒载量等重点指标全面向好，临床体征和症状明显好转。
但这种方式也并非万能神药，目前依然存在着诸多限制。
腾盛博药的联合创始人、总裁兼首席执行官洪志博士此前曾在接受医药魔方采访时表示，利用痊愈患者的血清来治疗其他感染患者是过去对抗多种感染性疾病的常见手段，但这类方法也存在一些危险，比如不同痊愈患者血清抗体量不一致，经过灭活的血清中仍含有其它一些潜在危险病源。
中科院上海巴斯德所此前也对媒体表示，虽然血清疗法可以较为有效的用来对抗或预防病毒或细菌引起的疾病，但血清成分复杂，对于是否会引起其他问题还存在不确定性，何况其存在的时间比较短，而且需要的血清数量也比较大。但是通过现代方法，可以通过分析治愈者的血液，拿到可以有效地中和病毒的全人源单克隆抗体序列，用以治疗和预防病毒引起的疾病的发生。
洪志也曾提及，现在技术上已经有了利用痊愈患者血液的更好手段，即从患者血液中提取出对病毒有记忆的B细胞，再把这类细胞产生的能够对抗病原体的抗体分离出来，进而用于治疗其他感染患者。
与直接用血清治疗相比，这是相对更安全的一种策略，因为可以对抗体进行标准化生产，还能够以标准化的剂量给药。但他也强调，拿到单抗并不意味着可以直接用于治疗其他患者，因为还要进行临床前以及临床I期健康人研究等验证。而想要大量生产这类抗体，也还需花很多时间和精力。一般来说，从发现这种抗体到使这类抗体能够在高产细胞中大量表达至少需要1年左右的时间。这对于应对突发性的疫情是非常不利的。
来源：综合澎湃新闻、界面新闻、
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Shanghai man discharged 7 days after infection: lucky to recover, willing to donate serum to save people

Beijing News
02-14 15:01 The official account of the Beijing News Agency
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Beijing News (Reporter Liu Haonan, Yu Jinzhen, Jin Qing) Today (February 14), a reporter from the Beijing News learned from the Shanghai Municipal Health Commission that 28 cases of newly diagnosed pneumonia were cured and discharged today. A total of 90 discharged cases were discharged, of which 6 Rehabilitated patients are willing to donate plasma to help with treatment and research. Donor Liu told the Beijing News reporter that he was very lucky to recover and was willing to donate serum, hoping that his serum could help treat critically ill patients.

Mr. Liu said he was willing to donate serum to help with treatment. Photo by Beijing News reporter Jinyu Yu
Today, Mr. Liu, a recoverer, was discharged from the Shanghai Public Health Clinical Center wearing a mask and explained to the Beijing News reporter his infection and recovery process. According to Mr. Liu, he visited a teacher in his hometown of Northeast China during the Chinese New Year, and his teacher's son was diagnosed with new coronary pneumonia on February 6. Mr. Liu took the initiative to go to the hospital for investigation. He was diagnosed on February 7 and was admitted to the hospital for treatment. After receiving 7 days of treatment, Mr. Liu was evaluated by the expert group and found that he met the criteria for de-isolation and discharge from confirmed cases.
Mr. Liu told the Beijing News reporter that he had visited the teacher's home for about 20 minutes. At that time, the teacher's son had left the house and had no direct contact. The teacher's son stayed in the parents' house for only one night, and he had no symptoms before being diagnosed.
According to Mr. Liu, the teacher's son had attended a conference in Beijing and many participants were diagnosed afterwards. Mr. Liu admits that no symptoms were found before the diagnosis. After visiting the teacher, he was informed of the relevant situation and was very worried. He decided to go to the hospital for investigation.
"The treatment is still very smooth. I am very fortunate to have recovered. After recovery, my serum may be helpful for the treatment of other patients, so I am willing to donate my serum." Mr Liu told reporters.
Proofreading Lu Qian
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Another 28 cured patients were discharged from Shanghai, and some cured patients offered to donate plasma
2020-02-14 17:02 North Vision New Vision Comprehensive TF019
Another 28 patients were discharged from Shanghai on the 14th. This is the largest number of patients recently discharged from Shanghai. As of press time, 90 patients in Shanghai have recovered. In addition, according to the latest report from the Shanghai Municipal Health Commission: No new confirmed cases in Shanghai at 0-12 on February 14th.

Data map Xinhua News Agency reporter Jin Mei Dorji
Regarding the issue of plasma of the rehabilitated people, Lu Hongzhou, member of the expert group of the National Health and Health Commission and secretary of the Party Committee of the Shanghai Public Health Clinical Center, said that six of the 14 patients admitted to the hospital were willing to donate plasma. Blood samples will then be collected within two to four weeks depending on the patient's physical condition.
"At present, plasma therapy may be valuable for patients, especially critically ill patients. Today's batch of discharged patients have offered to donate blood, which is very moving to me." He believes that the practice of recovering patients' blood donation to save people will Bring positive effects to treatment.
According to reports, on February 8th, based on the new crown pneumonia diagnosis and treatment plan (the fifth edition of the trial) as a guide, the first phase of the new crown special plasma treatment for 3 critically ill patients was carried out at the First People's Hospital in Jiangxia District, Wuhan, and is currently being treated with subsequent hospitals. More than 10 critically ill patients. Clinically, after 12 to 24 hours of treatment, the main inflammatory indicators in the laboratory decreased significantly, the proportion of lymphocytes increased, key indicators such as blood oxygen saturation and viral load improved, and clinical signs and symptoms improved significantly.
According to Lu Hongzhou, one patient in Shanghai is preparing to use the plasma of the recovering patient. "I look forward to the fact that plasma therapy can play a role in critically ill patients, especially critically ill patients."
Mr. Liu, who was discharged from the hospital this time, said, “It took me only 7 days from hospitalization to discharge. Thanks to all the medical staff for their care and care.” After learning that the plasma of the cured person could work for the critically ill patients, Mr. Liu signed up immediately. , I hope to give my own strength to treat other patients or help scientific research.
Shen Yinzhong, who returned home from Geneva on the morning of the 14th, is the director of the Medical Department of the Shanghai Public Health Clinical Center. This time, as the only expert in Mainland China, he participated in the formulation of the WHO clinical management guidelines for new coronavirus infections.
He told reporters, "We can understand the public's concern and expectation for plasma exchange, but this method is not uncommon. Many infectious diseases have been used before, and we have considered this method before." Shen Yinzhong said, Plasma The therapeutic effect of replacement on new coronary pneumonia has yet to be further observed. "It may have a certain effect, but don't expect to use a certain method to straighten new coronary pneumonia at once, or use comprehensive treatment as the principle."
Further reading:
On the evening of February 13, Zhang Dingyu, the director of Wuhan Jinyintan Hospital, stated that the Jinyintan Hospital is in the process of recovering patients' plasma during infusion, and it has also shown some preliminary results, because there are a large number of comprehensive antibodies in the patients during recovery to fight the virus.
Data map Xinhua News Agency reporter Jin Mei Dorji
This is also the first time since the outbreak of the new crown pneumonia outbreak that first-line medical experts have confirmed that "serum therapy" is used for clinical treatment.
In fact, in the fourth edition of the National Health and Health Commission's trial version of "Diagnosis and Treatment of New Coronavirus Infected Pneumonia," it has been officially proposed that treatment of severe and critically ill patients "can be used in the recovery period of plasma treatment."
The idea of using plasma transfusion for patients in rehabilitation for clinical treatment has actually existed during the fight against SARS.
Academician Zhong Nanshan had put forward a suggestion for treating SARS patients with the serum of recovered people at that time, and Tiantan Biological had also developed the SARS antiviral serum. Some hospitals in Hong Kong, China and Taiwan have also developed serum therapy for patients with severe SARS, and have achieved good results.
After the outbreak of the epidemic, the medical community was struggling to find medicines for the treatment of new coronavirus pneumonia, and many industry experts had suggested to interface journalists that the use of plasma transfusion therapy for patients in rehabilitation was an option.
To put it simply, there is currently no specific medicine for neocoronavirus pneumonia, and after the patient is infected with the virus, the autoimmune system will respond to the neocoronavirus and generate corresponding specific antibodies. When these neocoronavirus specific antibodies have sufficient scale , It is possible to defeat the new crown virus in the body.
In the blood of rehabilitation patients, there is often a large-scale neocoronavirus-specific antibody. By extracting their blood and processing their serum to a certain extent, the antibody in the blood of the rehabilitation patient can be given to the clinic through blood transfusion. Patients, helping patients with their own immune system to fight the new crown virus.
The vaccine that the public is concerned about is actually a traditional inactivated vaccine. It is also used to vaccinate the killed virus to the human body, and then the immune system produces corresponding antibodies. In contrast, the use of serum for rehabilitation patients is more direct. .
"China Bio" also announced on the evening of February 13 that it has completed the collection of plasma from some recoverers and carried out the preparation of neocrown virus-exclusive plasma products and exoglobulin. After rigorous blood biosafety testing, virus inactivation, and antiviral activity testing, special immune plasma has been successfully prepared for clinical treatment.
On February 8, using the new coronavirus-infected pneumonia diagnosis and treatment program (the fifth edition) as a guide, the first phase of the new crown-free plasma treatment of 3 critically ill patients was carried out in the First People's Hospital of Jiangxia District, and is currently being treated with subsequent hospital More than 10 critically ill patients. Clinically, after 12 to 24 hours of treatment, the main inflammatory indicators in the laboratory decreased significantly, the proportion of lymphocytes increased, key indicators such as blood oxygen saturation and viral load improved, and clinical signs and symptoms improved significantly.
But this method is not a panacea, and there are still many restrictions.
Dr. Hong Zhi, the co-founder, president and CEO of Tengshengbo Pharmaceuticals, previously said in an interview with the Rubik's Cube that using the recovered patient's serum to treat other infected patients was a common method to combat multiple infectious diseases in the past, but this There are also some dangers in this type of method, such as inconsistent serum antibody levels in different cured patients, and the inactivated serum still contains some other potentially dangerous sources.
The Pasteur Institute of the Chinese Academy of Sciences also previously told the media that although serum therapy can be more effective in combating or preventing diseases caused by viruses or bacteria, the composition of the serum is complex, and there are still uncertainties about whether it will cause other problems, let alone its It exists for a relatively short period of time and requires a large amount of serum. However, through modern methods, the blood of the healer can be analyzed to obtain a fully human monoclonal antibody sequence that can effectively neutralize the virus, in order to treat and prevent the disease caused by the virus.
Hong Zhi also mentioned that now there is a better way to use the blood of patients to heal, that is, to extract B cells that have memory of the virus from the patient's blood, and then to isolate the antibodies produced by these cells that can fight pathogens It can be used to treat other infected patients.
This is a relatively safe strategy compared to direct treatment with serum, because antibodies can be standardized for production and can be administered in standardized doses. However, he also emphasized that receiving monoclonal antibodies does not mean that it can be used directly in the treatment of other patients, because verifications such as preclinical and clinical Phase I healthy human studies are also required. It takes a lot of time and effort to produce such antibodies in large quantities. In general, it takes at least about one year from the discovery of this antibody to enabling such antibodies to be expressed in large numbers in high-yielding cells. This is very detrimental to responding to sudden outbreaks.
Zh
Source: Comprehensive surging news, interface news,
上海男子被感染7天后出院：康复很幸运，愿捐血清救人
新京报
02-14 15:01新京报社官方帐号
关注
新京报讯（记者 刘浩南 俞金旻 靳晴）今日（2月14日），新京报记者从上海市卫健委获悉，今日有28例新冠肺炎确诊病例治愈出院，出院病例累计90例，其中6个康复者愿意捐献血浆帮助治疗及研究。捐献者刘先生告诉新京报记者，自己能康复非常幸运，很愿意捐献血清，希望自己的血清能帮助治疗危重病人。
康复者刘先生称愿意捐献血清帮助治疗。新京报记者 俞金旻 摄
今日，康复者刘先生戴着口罩，从上海市公共卫生临床中心出院，向新京报记者详述自己感染及康复的过程。据刘先生介绍，他在过年期间曾到家乡东北拜访一位老师，这位老师的儿子于2月6日被确诊新冠肺炎。刘先生获悉后主动到医院排查，于2月7日被确诊，并入院接受治疗。刘先生接受7天治疗后，经专家组评估，认为其符合确诊病例解除隔离和出院标准。
刘先生告诉新京报记者，他到老师家中拜访时间大约为20分钟，当时老师的儿子已经离家，未直接接触。老师的儿子只在父母家中住过一晚，被确诊前无相关症状。
据刘先生称，老师的儿子曾在北京参加过一个会议，事后有多名参会者被确诊。刘先生坦承，被确诊前未发现症状，拜访完老师后获悉相关情况，心里非常忐忑，于是决定主动到医院排查。
“治疗还是非常顺利的，很幸运我康复了。康复之后，我的血清可能对其他患者的治疗有一定帮助，所以我愿意捐献我的血清。”刘先生告诉记者。
校对 卢茜
https://m.takefoto.cn/viewnews-2048519.html
上海又有28例痊愈患者出院，有治愈者主动提出捐献血浆
2020-02-14 17:02 北晚新视觉综合 TF019
上海14日又有28名患者治愈出院，这是上海近期出院的患者中人数最多的一批。截至记者发稿前，上海累计有90例患者痊愈。另据上海市卫健委最新通报：2月14日0—12时，上海市无新增确诊病例。
资料图 新华社记者 晋美多吉 摄
对于大众关注的康复者血浆问题，国家卫生健康委专家组成员、上海市公共卫生临床中心党委书记卢洪洲表示，14日出院患者中有6名愿意捐献血浆。之后将视患者身体状况，在两到四周内进行血液样本的采集。
“目前来看，血浆疗法对患者，尤其是重症患者或许是有价值的。今天的这批出院的患者主动提出可以捐血，令我非常感动。”他认为，痊愈患者献血救人的做法，将给治疗带来积极作用。
据报道，2月8日，以新冠肺炎诊疗方案(试行第五版)为指南，首期在武汉江夏区第一人民医院开展了3名危重患者的新冠特免血浆治疗，目前连同后续医院治疗的危重病人超过了10人。临床反映，患者接受治疗12至24小时后，实验室检测主要炎症指标明显下降，淋巴细胞比例上升，血氧饱和度、病毒载量等重点指标全面向好，临床体征和症状明显好转。
卢洪洲介绍，上海已有一例患者准备使用恢复期患者的血浆，“我期待着血浆疗法能够对重症患者尤其是危重症患者起到一定作用”。
此次出院患者刘先生表示，“从住院到出院，我只用了7天，感谢所有医务人员的关心和照顾。”在得知治愈者的血浆能够对危重患者起作用后，刘先生立即报名，希望献出自己的力量，用于救治其他患者或帮助科学研究。
14日早晨从日内瓦参会回国的沈银忠是上海市公共卫生临床中心医务部主任，这次也作为中国内地唯一专家参与了制定WHO新型冠状病毒感染临床管理指南。
他向记者介绍，“我们可以理解公众对血浆置换术的关心和期待，但是这种方法并不稀奇，之前很多传染病都在用，我们之前早就考虑过这种方法。”沈银忠说，血浆置换对新冠肺炎的治疗效果，还有待后续进一步观察，“可能会有一定的效果，但不要寄希望于使用某种方法就可以一下子摆平新冠肺炎，还是要以综合治疗为原则。”
延伸阅读：
2月13日晚，武汉金银潭医院院长张定宇对外表示，金银潭医院正在开展康复病人的恢复期血浆输注，目前也显示出一些初步效果，因为康复期患者体内有大量综合抗体来对抗病毒。
资料图 新华社记者 晋美多吉 摄
这也是新冠肺炎疫情爆发以来，首次有一线医疗专家确认了“血清疗法”用于临床救治。
实际上，在国家卫健委发布试行第四版的《新型冠状病毒感染的肺炎诊疗方案》中就已经正式提出，对重型、危重型病人治疗措施“可采用恢复期血浆治疗”。
使用康复期患者的血浆输注进行临床治疗的思路，在抗击SARS疫情时期实际上就已有之。
钟南山院士就曾在当时提出过用康复者血清治疗SARS患者的建议，天坛生物也曾研制SARS抗病毒血清。中国香港和台湾地区的一些医院也曾对SARS重病患开展过血清疗法，并取得了不错的疗效。
在疫情爆发后医药界苦苦寻找治疗新冠病毒肺炎药物时，就有多位行业专家曾对界面新闻记者提出，使用康复期患者的血浆输注治疗是一个选择。
简单来说，目前对于新冠病毒肺炎没有特效药，而患者在被病毒感染后，自身免疫系统会针对新冠病毒出现免疫应答，产生相应的特异性抗体，当这些新冠病毒特异性抗体具备足够规模时，就有可能战胜体内的新冠病毒。
而康复患者体内血液中往往就存在着足够规模的新冠病毒特异性抗体，通过对他们的血液抽取，对其血清进行一定的处理，便可以通过输血的方式把康复者血液中的抗体给到临床病人，帮助患者自身免疫系统对抗新冠病毒。
大众所关切的疫苗，实际上以传统的灭活疫苗为例，也是将被杀死病毒以疫苗方式接种人体，随后由免疫系统产生相应抗体，相比之下使用康复患者的血清治疗则更加直接。
“中国生物”也在2月13日晚宣布，已完成对部分康复者血浆的采集工作，开展新冠病毒特免血浆制品和特免球蛋白的制备。经过严格的血液生物安全性检测，病毒灭活，抗病毒活性检测等，已成功制备出用于临床治疗的特免血浆。
2月8日，以新型冠状病毒感染的肺炎诊疗方案（试行第五版）为指南，首期在江夏区第一人民医院开展了3名危重患者的新冠特免血浆治疗，目前连同后续医院治疗的危重病人超过了10人。临床反映，患者接受治疗12至24小时后，实验室检测主要炎症指标明显下降，淋巴细胞比例上升，血氧饱和度、病毒载量等重点指标全面向好，临床体征和症状明显好转。
但这种方式也并非万能神药，目前依然存在着诸多限制。
腾盛博药的联合创始人、总裁兼首席执行官洪志博士此前曾在接受医药魔方采访时表示，利用痊愈患者的血清来治疗其他感染患者是过去对抗多种感染性疾病的常见手段，但这类方法也存在一些危险，比如不同痊愈患者血清抗体量不一致，经过灭活的血清中仍含有其它一些潜在危险病源。
中科院上海巴斯德所此前也对媒体表示，虽然血清疗法可以较为有效的用来对抗或预防病毒或细菌引起的疾病，但血清成分复杂，对于是否会引起其他问题还存在不确定性，何况其存在的时间比较短，而且需要的血清数量也比较大。但是通过现代方法，可以通过分析治愈者的血液，拿到可以有效地中和病毒的全人源单克隆抗体序列，用以治疗和预防病毒引起的疾病的发生。
洪志也曾提及，现在技术上已经有了利用痊愈患者血液的更好手段，即从患者血液中提取出对病毒有记忆的B细胞，再把这类细胞产生的能够对抗病原体的抗体分离出来，进而用于治疗其他感染患者。
与直接用血清治疗相比，这是相对更安全的一种策略，因为可以对抗体进行标准化生产，还能够以标准化的剂量给药。但他也强调，拿到单抗并不意味着可以直接用于治疗其他患者，因为还要进行临床前以及临床I期健康人研究等验证。而想要大量生产这类抗体，也还需花很多时间和精力。一般来说，从发现这种抗体到使这类抗体能够在高产细胞中大量表达至少需要1年左右的时间。这对于应对突发性的疫情是非常不利的。
来源：综合澎湃新闻、界面新闻、
https://baijiahao.baidu.com/s?id=1658494640043270093&wfr=spider&for=pc&isFailFlag=1
Shanghai man discharged 7 days after infection: lucky to recover, willing to donate serum to save people

Beijing News
02-14 15:01 The official account of the Beijing News Agency
attention
Beijing News (Reporter Liu Haonan, Yu Jinzhen, Jin Qing) Today (February 14), a reporter from the Beijing News learned from the Shanghai Municipal Health Commission that 28 cases of newly diagnosed pneumonia were cured and discharged today. A total of 90 discharged cases were discharged, of which 6 Rehabilitated patients are willing to donate plasma to help with treatment and research. Donor Liu told the Beijing News reporter that he was very lucky to recover and was willing to donate serum, hoping that his serum could help treat critically ill patients.

Mr. Liu said he was willing to donate serum to help with treatment. Photo by Beijing News reporter Jinyu Yu
Today, Mr. Liu, a recoverer, was discharged from the Shanghai Public Health Clinical Center wearing a mask and explained to the Beijing News reporter his infection and recovery process. According to Mr. Liu, he visited a teacher in his hometown of Northeast China during the Chinese New Year, and his teacher's son was diagnosed with new coronary pneumonia on February 6. Mr. Liu took the initiative to go to the hospital for investigation. He was diagnosed on February 7 and was admitted to the hospital for treatment. After receiving 7 days of treatment, Mr. Liu was evaluated by the expert group and found that he met the criteria for de-isolation and discharge from confirmed cases.
Mr. Liu told the Beijing News reporter that he had visited the teacher's home for about 20 minutes. At that time, the teacher's son had left the house and had no direct contact. The teacher's son stayed in the parents' house for only one night, and he had no symptoms before being diagnosed.
According to Mr. Liu, the teacher's son had attended a conference in Beijing and many participants were diagnosed afterwards. Mr. Liu admits that no symptoms were found before the diagnosis. After visiting the teacher, he was informed of the relevant situation and was very worried. He decided to go to the hospital for investigation.
"The treatment is still very smooth. I am very fortunate to have recovered. After recovery, my serum may be helpful for the treatment of other patients, so I am willing to donate my serum." Mr Liu told reporters.
Proofreading Lu Qian
https://m.takefoto.cn/viewnews-2048519.html
Another 28 cured patients were discharged from Shanghai, and some cured patients offered to donate plasma
2020-02-14 17:02 North Vision New Vision Comprehensive TF019
Another 28 patients were discharged from Shanghai on the 14th. This is the largest number of patients recently discharged from Shanghai. As of press time, 90 patients in Shanghai have recovered. In addition, according to the latest report from the Shanghai Municipal Health Commission: No new confirmed cases in Shanghai at 0-12 on February 14th.

Data map Xinhua News Agency reporter Jin Mei Dorji
Regarding the issue of plasma of the rehabilitated people, Lu Hongzhou, member of the expert group of the National Health and Health Commission and secretary of the Party Committee of the Shanghai Public Health Clinical Center, said that six of the 14 patients admitted to the hospital were willing to donate plasma. Blood samples will then be collected within two to four weeks depending on the patient's physical condition.
"At present, plasma therapy may be valuable for patients, especially critically ill patients. Today's batch of discharged patients have offered to donate blood, which is very moving to me." He believes that the practice of recovering patients' blood donation to save people will Bring positive effects to treatment.
According to reports, on February 8th, based on the new crown pneumonia diagnosis and treatment plan (the fifth edition of the trial) as a guide, the first phase of the new crown special plasma treatment for 3 critically ill patients was carried out at the First People's Hospital in Jiangxia District, Wuhan, and is currently being treated with subsequent hospitals. More than 10 critically ill patients. Clinically, after 12 to 24 hours of treatment, the main inflammatory indicators in the laboratory decreased significantly, the proportion of lymphocytes increased, key indicators such as blood oxygen saturation and viral load improved, and clinical signs and symptoms improved significantly.
According to Lu Hongzhou, one patient in Shanghai is preparing to use the plasma of the recovering patient. "I look forward to the fact that plasma therapy can play a role in critically ill patients, especially critically ill patients."
Mr. Liu, who was discharged from the hospital this time, said, “It took me only 7 days from hospitalization to discharge. Thanks to all the medical staff for their care and care.” After learning that the plasma of the cured person could work for the critically ill patients, Mr. Liu signed up immediately. , I hope to give my own strength to treat other patients or help scientific research.
Shen Yinzhong, who returned home from Geneva on the morning of the 14th, is the director of the Medical Department of the Shanghai Public Health Clinical Center. This time, as the only expert in Mainland China, he participated in the formulation of the WHO clinical management guidelines for new coronavirus infections.
He told reporters, "We can understand the public's concern and expectation for plasma exchange, but this method is not uncommon. Many infectious diseases have been used before, and we have considered this method before." Shen Yinzhong said, Plasma The therapeutic effect of replacement on new coronary pneumonia has yet to be further observed. "It may have a certain effect, but don't expect to use a certain method to straighten new coronary pneumonia at once, or use comprehensive treatment as the principle."
Further reading:
On the evening of February 13, Zhang Dingyu, the director of Wuhan Jinyintan Hospital, stated that the Jinyintan Hospital is in the process of recovering patients' plasma during infusion, and it has also shown some preliminary results, because there are a large number of comprehensive antibodies in the patients during recovery to fight the virus.
Data map Xinhua News Agency reporter Jin Mei Dorji
This is also the first time since the outbreak of the new crown pneumonia outbreak that first-line medical experts have confirmed that "serum therapy" is used for clinical treatment.
In fact, in the fourth edition of the National Health and Health Commission's trial version of "Diagnosis and Treatment of New Coronavirus Infected Pneumonia," it has been officially proposed that treatment of severe and critically ill patients "can be used in the recovery period of plasma treatment."
The idea of using plasma transfusion for patients in rehabilitation for clinical treatment has actually existed during the fight against SARS.
Academician Zhong Nanshan had put forward a suggestion for treating SARS patients with the serum of recovered people at that time, and Tiantan Biological had also developed the SARS antiviral serum. Some hospitals in Hong Kong, China and Taiwan have also developed serum therapy for patients with severe SARS, and have achieved good results.
After the outbreak of the epidemic, the medical community was struggling to find medicines for the treatment of new coronavirus pneumonia, and many industry experts had suggested to interface journalists that the use of plasma transfusion therapy for patients in rehabilitation was an option.
To put it simply, there is currently no specific medicine for neocoronavirus pneumonia, and after the patient is infected with the virus, the autoimmune system will respond to the neocoronavirus and generate corresponding specific antibodies. When these neocoronavirus specific antibodies have sufficient scale , It is possible to defeat the new crown virus in the body.
In the blood of rehabilitation patients, there is often a large-scale neocoronavirus-specific antibody. By extracting their blood and processing their serum to a certain extent, the antibody in the blood of the rehabilitation patient can be given to the clinic through blood transfusion. Patients, helping patients with their own immune system to fight the new crown virus.
The vaccine that the public is concerned about is actually a traditional inactivated vaccine. It is also used to vaccinate the killed virus to the human body, and then the immune system produces corresponding antibodies. In contrast, the use of serum for rehabilitation patients is more direct. .
"China Bio" also announced on the evening of February 13 that it has completed the collection of plasma from some recoverers and carried out the preparation of neocrown virus-exclusive plasma products and exoglobulin. After rigorous blood biosafety testing, virus inactivation, and antiviral activity testing, special immune plasma has been successfully prepared for clinical treatment.
On February 8, using the new coronavirus-infected pneumonia diagnosis and treatment program (the fifth edition) as a guide, the first phase of the new crown-free plasma treatment of 3 critically ill patients was carried out in the First People's Hospital of Jiangxia District, and is currently being treated with subsequent hospital More than 10 critically ill patients. Clinically, after 12 to 24 hours of treatment, the main inflammatory indicators in the laboratory decreased significantly, the proportion of lymphocytes increased, key indicators such as blood oxygen saturation and viral load improved, and clinical signs and symptoms improved significantly.
But this method is not a panacea, and there are still many restrictions.
Dr. Hong Zhi, the co-founder, president and CEO of Tengshengbo Pharmaceuticals, previously said in an interview with the Rubik's Cube that using the recovered patient's serum to treat other infected patients was a common method to combat multiple infectious diseases in the past, but this There are also some dangers in this type of method, such as inconsistent serum antibody levels in different cured patients, and the inactivated serum still contains some other potentially dangerous sources.
The Pasteur Institute of the Chinese Academy of Sciences also previously told the media that although serum therapy can be more effective in combating or preventing diseases caused by viruses or bacteria, the composition of the serum is complex, and there are still uncertainties about whether it will cause other problems, let alone its It exists for a relatively short period of time and requires a large amount of serum. However, through modern methods, the blood of the healer can be analyzed to obtain a fully human monoclonal antibody sequence that can effectively neutralize the virus, in order to treat and prevent the disease caused by the virus.
Hong Zhi also mentioned that now there is a better way to use the blood of patients to heal, that is, to extract B cells that have memory of the virus from the patient's blood, and then to isolate the antibodies produced by these cells that can fight pathogens It can be used to treat other infected patients.
This is a relatively safe strategy compared to direct treatment with serum, because antibodies can be standardized for production and can be administered in standardized doses. However, he also emphasized that receiving monoclonal antibodies does not mean that it can be used directly in the treatment of other patients, because verifications such as preclinical and clinical Phase I healthy human studies are also required. It takes a lot of time and effort to produce such antibodies in large quantities. In general, it takes at least about one year from the discovery of this antibody to enabling such antibodies to be expressed in large numbers in high-yielding cells. This is very detrimental to responding to sudden outbreaks.
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Source: Comprehensive surging news, interface news,
