Hi Bros & Johnny333
my wife has been taking Allopurinol Tab 300mg x 2 tabs
each morning . i am thinking what side effect will she get.
she has been taking it for 15 years already .
Thanks bro
I took that too
but only 2x100mg. I used to have gout but already years under control. The only side effect is red rashes and swelling lips some times. When large chuck of purine acids melted by Allopurinol travels in blood to skin, it irritates skin like hell. But antihistamine can take care of this side effects if necessary. Drink lots of water especially barley water, to pee out the purine.
Allopurinol is mild alkaline, and purine is acid, that's is how I think it works
. It converts purine (uric acid) into something that you can pee out via urine.
If your wife already took it for 15 years, she should be expected to be stable and well adjusted to Allopurinol by now. I took for 2 - 3 years and then do periodic blood tests to monitor uric acid level. SGH specialist thinks I have healed, and they discharged my case to polyclinics already, but I have yet visited polyclinics doctors since.
I still have the Allopurinol pills. But my is 100mg. In 1990s when I ate lots of beef and mutton, my purine went sky high and got gout attacks. I have spent years to treat that.:p
Nice food are unhealthy!
http://en.wikipedia.org/wiki/Allopurinol
Mechanism of action
Allopurinol is a structural
isomer of
hypoxanthine (a naturally occurring
purine in the body) and is an
enzyme inhibitor, inhibiting
xanthine oxidase.<sup id="cite_ref-pmid16507884_0-1" class="reference">
[1]</sup> Xanthine oxidase is responsible for the successive oxidation of hypoxanthine and
xanthine resulting in the production of
uric acid, the product of human purine metabolism.<sup id="cite_ref-pmid16507884_0-2" class="reference">
[1]</sup> In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine, which are converted to closely related purine
ribotides adenosine and
guanosine monophosphates. Increased levels of these ribotides causes feedback inhibition of
amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Allopurinol therefore decreases both uric acid formation and purine synthesis.
Side effects
Side effects of allopurinol are rare, though significant when they occur. A small percentage of people develop a rash and must discontinue this drug. The most serious adverse effect is a hypersensitivity syndrome consisting of fever, skin rash,
eosinophilia,
hepatitis, worsened renal function and, in some cases, allopurinol hypersensitivity syndrome. Allopurinol is one of the drugs commonly known to cause
Stevens-Johnson syndrome (SJS) and
toxic epidermal necrolysis (TENS), two life-threatening
dermatological conditions.
Allopurinol can cause severe
pancytopenia if given with
azathioprine or
mercaptopurine, due to inhibition of xanthine oxidase which metabolizes these drugs. It can also cause breast enlargement in both males and females.
Allopurinol can lower
blood pressure in mild
hypertension.<sup id="cite_ref-Journal_Watch_Specialties_2-0" class="reference">
[3]</sup>
