- Joined
- Jul 16, 2008
- Messages
- 25,040
- Points
- 113
https://www.amazon.com/dp/B07VXJKPYN/
https://www.amazon.sg/AVMACOL®-Bottle-Sulforaphane-Supplement-Myrosinase/dp/B07VXJKPYN/
Dr Rhonda Patrick
put in a lot of effort in making this video presentation, including typing out this timeline herself :
00:00:34 - Introduction of sulforaphane, a major focus of the video.
00:01:14 - Cruciferous vegetable consumption and reductions in all-cause mortality.
00:02:12 - Prostate cancer risk.
00:02:23 - Bladder cancer risk.
00:02:34 - Lung cancer in smokers risk.
00:02:48 - Breast cancer risk.
00:03:13 - Hypothetical: what if you already have cancer? (interventional)
00:03:35 - Plausible mechanism driving the cancer and mortality associative data.
00:04:38 - Sulforaphane and cancer.
00:05:32 - Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
00:06:06 - Effect of direct supplementation of sulforaphane in prostate cancer patients.
00:07:09 - Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
00:08:32 - Inhibition of breast cancer stem cells.
00:08:53 - History lesson: brassicas were established as having health properties even in ancient Rome.
00:09:16 - Sulforaphane's ability to enhance carcinogen excretion (benzene, acrolein).
00:09:51 - NRF2 as a genetic switch via antioxidant response elements.
00:10:10 - How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
00:10:34 - Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
00:11:20 - Broccoli sprout drink increases benzene excretion by 61%.
00:13:31 - Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
00:15:45 - Cruciferous vegetable consumption and heart disease mortality.
00:16:55 - Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
00:19:04 - Beginning of aging section.
00:19:21 - Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
00:20:34 - Importance of low inflammation for longevity.
00:22:05 - Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
00:23:40 - Mid-video recap: cancer, aging sections
00:24:14 - Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
00:25:18 - Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
00:26:30 - Beginning of brain and behavior section.
00:27:18 - Effect of broccoli sprout extract on autism.
00:27:48 - Effect of glucoraphanin on schizophrenia.
00:28:17 - Start of depression discussion (plausible mechanism and studies).
00:31:21 - Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
00:32:00 - Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
00:33:01 - Beginning of neurodegeneration section.
00:33:30 - Sulforaphane and Alzheimer's disease.
00:33:44 - Sulforaphane and Parkinson's disease.
00:33:51 - Sulforaphane and Hungtington's disease.
00:34:13 - Sulforaphane increases heat shock proteins.
00:34:43 - Beginning of traumatic brain injury section.
00:35:01 - Sulforaphane injected immediately after TBI improves memory (mouse study).
00:35:55 - Sulforaphane and neuronal plasticity.
00:36:32 - Sulforaphane improves learning in model of type II diabetes in mice.
00:37:19 - Sulforaphane and duchenne muscular dystrophy.
00:37:44 - Myostatin inhibition in muscle satellite cells (in vitro).
00:38:06 - Late-video recap: mortality and cancer, DNA damage, oxidative stress and inflammation, benzene excretion, cardiovascular disease, type II diabetes, effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
00:40:27 - Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
00:41:01 - Anecdotes on sprouting at home.
00:43:14 - On cooking temperatures and sulforaphane activity.
00:43:45 - Gut bacteria conversion of sulforaphane from glucoraphanin.
00:44:24 - Supplements work better when combined with active myrosinase from vegetables.
00:44:56 - Cooking techniques and cruciferous vegetables.
00:46:06 - Isothiocyanates as goitrogens.
https://www.amazon.com/dp/B07VXJKPYN/
https://www.amazon.sg/AVMACOL®-Bottle-Sulforaphane-Supplement-Myrosinase/dp/B07VXJKPYN/
https://www.amazon.sg/AVMACOL®-Bottle-Sulforaphane-Supplement-Myrosinase/dp/B07VXJKPYN/
Dr Rhonda Patrick
put in a lot of effort in making this video presentation, including typing out this timeline herself :
00:00:34 - Introduction of sulforaphane, a major focus of the video.
00:01:14 - Cruciferous vegetable consumption and reductions in all-cause mortality.
00:02:12 - Prostate cancer risk.
00:02:23 - Bladder cancer risk.
00:02:34 - Lung cancer in smokers risk.
00:02:48 - Breast cancer risk.
00:03:13 - Hypothetical: what if you already have cancer? (interventional)
00:03:35 - Plausible mechanism driving the cancer and mortality associative data.
00:04:38 - Sulforaphane and cancer.
00:05:32 - Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
00:06:06 - Effect of direct supplementation of sulforaphane in prostate cancer patients.
00:07:09 - Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
00:08:32 - Inhibition of breast cancer stem cells.
00:08:53 - History lesson: brassicas were established as having health properties even in ancient Rome.
00:09:16 - Sulforaphane's ability to enhance carcinogen excretion (benzene, acrolein).
00:09:51 - NRF2 as a genetic switch via antioxidant response elements.
00:10:10 - How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
00:10:34 - Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
00:11:20 - Broccoli sprout drink increases benzene excretion by 61%.
00:13:31 - Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
00:15:45 - Cruciferous vegetable consumption and heart disease mortality.
00:16:55 - Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
00:19:04 - Beginning of aging section.
00:19:21 - Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
00:20:34 - Importance of low inflammation for longevity.
00:22:05 - Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
00:23:40 - Mid-video recap: cancer, aging sections
00:24:14 - Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
00:25:18 - Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
00:26:30 - Beginning of brain and behavior section.
00:27:18 - Effect of broccoli sprout extract on autism.
00:27:48 - Effect of glucoraphanin on schizophrenia.
00:28:17 - Start of depression discussion (plausible mechanism and studies).
00:31:21 - Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
00:32:00 - Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
00:33:01 - Beginning of neurodegeneration section.
00:33:30 - Sulforaphane and Alzheimer's disease.
00:33:44 - Sulforaphane and Parkinson's disease.
00:33:51 - Sulforaphane and Hungtington's disease.
00:34:13 - Sulforaphane increases heat shock proteins.
00:34:43 - Beginning of traumatic brain injury section.
00:35:01 - Sulforaphane injected immediately after TBI improves memory (mouse study).
00:35:55 - Sulforaphane and neuronal plasticity.
00:36:32 - Sulforaphane improves learning in model of type II diabetes in mice.
00:37:19 - Sulforaphane and duchenne muscular dystrophy.
00:37:44 - Myostatin inhibition in muscle satellite cells (in vitro).
00:38:06 - Late-video recap: mortality and cancer, DNA damage, oxidative stress and inflammation, benzene excretion, cardiovascular disease, type II diabetes, effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
00:40:27 - Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
00:41:01 - Anecdotes on sprouting at home.
00:43:14 - On cooking temperatures and sulforaphane activity.
00:43:45 - Gut bacteria conversion of sulforaphane from glucoraphanin.
00:44:24 - Supplements work better when combined with active myrosinase from vegetables.
00:44:56 - Cooking techniques and cruciferous vegetables.
00:46:06 - Isothiocyanates as goitrogens.
https://www.amazon.com/dp/B07VXJKPYN/
https://www.amazon.sg/AVMACOL®-Bottle-Sulforaphane-Supplement-Myrosinase/dp/B07VXJKPYN/
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