So biological signature can be changed and edited. Evidence can be destroyed or erased. Terrorist and suspects can NOT BE TRACED any more via DNA. Plastic Surgery can change a person's look, ID passport license can be forged, DNA can change. Finger prints can be destroyed (Ask the mother of Huang Na, in Tok Liang How murder case), a person can vanish just like that.
DNA can be edited meaning it can be RE-EDITED repeatedly.
It means also that corpse identification can become impossible. How can CIS mata know if the DNA corpse they found had not been edited before the person being killed? How does it work? I can kidnap you, modify your DNA, kill you afterwards, destroy your skull including dental feature, burn off your finger prints. CSI cops won't be able to know who's corpse they had found!
http://edition.cnn.com/2017/11/15/health/first-in-body-edit-dna/index.html
Medical first: Doctors attempt to gene-edit a living patient's DNA
By Susan Scutti, CNN
Updated 1357 GMT (2157 HKT) November 16, 2017
This is what makes your body unique 01:26
Story highlights
From Madeux's point of view, the revolutionary treatment appears anything but: It was a simple matter of getting hooked up to an IV, which delivered a gene editor into his bloodstream along with copies of a corrected gene to replace the mutation he carries that is responsible for the disorder.
"The infusion takes place for anywhere from two to three hours. And that's it," said Dr. Edward Conner, senior vice president and chief medical officer of Sangamo Therapeutics, maker of the new therapy. "We're very hopeful."
Brian Madeux sits with his girlfriend Marcie Humphrey while waiting to receive the first human gene editing therapy at the UCSF Benioff Children's Hospital in Oakland, California.
Hunter syndrome
Hunter syndrome patients are missing the enzyme that breaks down mucopolysaccharides, chains of sugar molecules that are used to build connective tissues.
"If you think of your cell as a house, and over time, trash accumulates, this enzyme sort of helps take out the trash," Conner said. "If you don't have it, the trash builds up, builds up, and this happens in a lot of different tissues like the heart, like the brain."
Physical symptoms can include hearing problems, bone and joint malformation, and heart and breathing difficulties, according to Terri L. Klein, interim president and director of development and operations at the National MPS Society.
Scientists edit gene for blood disease in human embryos
"As the disease progresses, there is widespread damage throughout the body, including the heart, bones, joints, respiratory system and central nervous system, leading to a shortened lifespan," Klein wrote in an email.
There is no cure for Hunter syndrome, but it can be managed and treated with enzyme replacement therapies. Still, even patients who receive regular treatments undergo progressive damage to their hearts, bones and lungs.
"Many patients with MPS II die of airway obstruction, upper respiratory infection or heart failure before they reach the age of 20," said Dr. Paul Harmatz, Madeux's doctor, principal investigator for the study of the treatment and a pediatric gastroenterologist at the UCSF Benioff Children's Hospital Oakland.
Conner noted that Hunter syndrome primarily affects males: One in every 100,000 to 170,000 boys is born with this genetic disease.
FDA announces first US gene therapy approval for cancer treatment
"It is hard to define the number of patients affected," Klein said. "There are hundreds of boys throughout the United States and possibly thousands in the world." In extremely rare cases, girls may be affected.
Conner explained that "it's also a monogenetic disease: You have a mutation in one gene." This simplicity is helpful when testing the experimental gene therapy, he said, but there's another good reason to target Hunter syndrome: Patients are "still suffering quite a bit," he said, Madeux among them.
Testing the gene editor
As the first participant, Madeux is taking part in a study in which scientists examine whether the gene therapy -- which has not been approved by the US Food and Drug Administration for medical use -- is safe and effective for humans. Madeux declined a request to be interviewed for this story.
The DNA-editing technology is not the headline-grabbing CRISPR but one developed by Sangamo. It is based on naturally occurring proteins called zinc finger DNA-binding proteins.
Scientists edit disease-causing gene mutation in human embryos
These are "what your own body uses to identify sections of DNA that need to be modified or repaired," Conner explained. The new technology uses "zinc finger technology" to snip the DNA and stitch in the gene lacking in patients with Hunter syndrome.
The technology must be "as precise, efficient and specific as possible," he said. "Precise meaning it only targets a unique section of DNA. We have 30,000 genes in our body, and you want to make sure you are precise in where this acts."
The gene editor must be efficient or productive when it goes to work and specific in that "it only cuts at that site and is not editing elsewhere in the DNA," Conner said.
The zinc finger technology is delivered by a non-replicating, non-pathogenic virus: one that doesn't make you sick and one that is commonly used by gene therapy scientists, Conner said.
FDA panel unanimously votes to approve gene therapy for blindness
He noted that it was tested first in mice and non-human primates, and the safety of the treatment and clinical trial was vetted by the National Institutes of Health.
Harmatz said, "The infusion was on Monday. We observed Madeux for 24 hours in the hospital, and he looked fine when he left for his hotel (Tuesday). He hasn't had any problems so far."
One shot at success
Going forward, Harmatz said, he will be monitoring levels of enzymes in Madeux's circulating white blood cells, and in three months, he will perform a liver biopsy to see whether the corrected gene has integrated and started producing enzymes.
"We're very early in testing this first trial," Harmatz said. "I'm hopeful that we'll have some production." Since Madeux has shown no difficulties, Harmatz believes all should continue to go well.
However, he is concerned that the dose "was not enough and it turns out to be ineffective and not a benefit to him. You have one shot, one chance to have an effective therapy."
'Three-parent' babies approved in the UK
He explained that you can't come back in two months with a higher dose delivered and hope you get a better response, because after the first infusion, a patient becomes immune to the virus, so it's no longer an effective delivery system.
"People are working very hard to solve this problem," Harmatz said. Still, in about two or three months, he and Conner should know whether the treatment worked.
Dr. Sanjeev Gupta, a professor of medicine and pathology at Albert Einstein College of Medicine and Montefiore Health System, said "this is an exciting step for a long-awaited holy grail of successful gene therapy that has lasting benefit." Gupta, who was not involved in the study, added that whether the technology will be "effective (in the body) remains to be seen."
Along with the difficulties related to the "viral vectors used to insert gene sequences into cells," Gupta noted that "the biology of liver cells is such that multiple copies of any given gene may exist in a single cell. Whether these multiple gene copies could be corrected in sufficient cell numbers could be a key to treatment outcome here.
Follow CNN Health on Facebook and Twitter
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"But without studies that are carefully conducted, we would not be able to know that," he said.
Conner said Sangamo is continuing to screen Hunter syndrome patients to follow Medeux as participants in the study. Meanwhile, they have begun a clinical trial for a similar gene editing treatment focusing on hemophilia B patients.
"We're very, very excited," Conner said. "I'm honored and humbled by Madeux's decision to participate."
Klein also said that "Brian Madeux is very, very brave." Thankful to Sangamo for championing the cause, she believes this first run of gene therapy is a "leap forward."
"It is a new world of science," Klein said. "Someone needs to be on the front line, and Brian has rose to the occasion."
DNA can be edited meaning it can be RE-EDITED repeatedly.
It means also that corpse identification can become impossible. How can CIS mata know if the DNA corpse they found had not been edited before the person being killed? How does it work? I can kidnap you, modify your DNA, kill you afterwards, destroy your skull including dental feature, burn off your finger prints. CSI cops won't be able to know who's corpse they had found!
http://edition.cnn.com/2017/11/15/health/first-in-body-edit-dna/index.html
Medical first: Doctors attempt to gene-edit a living patient's DNA
By Susan Scutti, CNN
Updated 1357 GMT (2157 HKT) November 16, 2017
This is what makes your body unique 01:26
Story highlights
- The gene editing technology is based on naturally occurring proteins in the body
- Hunter syndrome is a rare genetic disease that primarily affects boys
From Madeux's point of view, the revolutionary treatment appears anything but: It was a simple matter of getting hooked up to an IV, which delivered a gene editor into his bloodstream along with copies of a corrected gene to replace the mutation he carries that is responsible for the disorder.
"The infusion takes place for anywhere from two to three hours. And that's it," said Dr. Edward Conner, senior vice president and chief medical officer of Sangamo Therapeutics, maker of the new therapy. "We're very hopeful."
Brian Madeux sits with his girlfriend Marcie Humphrey while waiting to receive the first human gene editing therapy at the UCSF Benioff Children's Hospital in Oakland, California.
Hunter syndrome
Hunter syndrome patients are missing the enzyme that breaks down mucopolysaccharides, chains of sugar molecules that are used to build connective tissues.
"If you think of your cell as a house, and over time, trash accumulates, this enzyme sort of helps take out the trash," Conner said. "If you don't have it, the trash builds up, builds up, and this happens in a lot of different tissues like the heart, like the brain."
Physical symptoms can include hearing problems, bone and joint malformation, and heart and breathing difficulties, according to Terri L. Klein, interim president and director of development and operations at the National MPS Society.
Scientists edit gene for blood disease in human embryos
"As the disease progresses, there is widespread damage throughout the body, including the heart, bones, joints, respiratory system and central nervous system, leading to a shortened lifespan," Klein wrote in an email.
There is no cure for Hunter syndrome, but it can be managed and treated with enzyme replacement therapies. Still, even patients who receive regular treatments undergo progressive damage to their hearts, bones and lungs.
"Many patients with MPS II die of airway obstruction, upper respiratory infection or heart failure before they reach the age of 20," said Dr. Paul Harmatz, Madeux's doctor, principal investigator for the study of the treatment and a pediatric gastroenterologist at the UCSF Benioff Children's Hospital Oakland.
Conner noted that Hunter syndrome primarily affects males: One in every 100,000 to 170,000 boys is born with this genetic disease.
FDA announces first US gene therapy approval for cancer treatment
"It is hard to define the number of patients affected," Klein said. "There are hundreds of boys throughout the United States and possibly thousands in the world." In extremely rare cases, girls may be affected.
Conner explained that "it's also a monogenetic disease: You have a mutation in one gene." This simplicity is helpful when testing the experimental gene therapy, he said, but there's another good reason to target Hunter syndrome: Patients are "still suffering quite a bit," he said, Madeux among them.
Testing the gene editor
As the first participant, Madeux is taking part in a study in which scientists examine whether the gene therapy -- which has not been approved by the US Food and Drug Administration for medical use -- is safe and effective for humans. Madeux declined a request to be interviewed for this story.
The DNA-editing technology is not the headline-grabbing CRISPR but one developed by Sangamo. It is based on naturally occurring proteins called zinc finger DNA-binding proteins.
Scientists edit disease-causing gene mutation in human embryos
These are "what your own body uses to identify sections of DNA that need to be modified or repaired," Conner explained. The new technology uses "zinc finger technology" to snip the DNA and stitch in the gene lacking in patients with Hunter syndrome.
The technology must be "as precise, efficient and specific as possible," he said. "Precise meaning it only targets a unique section of DNA. We have 30,000 genes in our body, and you want to make sure you are precise in where this acts."
The gene editor must be efficient or productive when it goes to work and specific in that "it only cuts at that site and is not editing elsewhere in the DNA," Conner said.
The zinc finger technology is delivered by a non-replicating, non-pathogenic virus: one that doesn't make you sick and one that is commonly used by gene therapy scientists, Conner said.
FDA panel unanimously votes to approve gene therapy for blindness
He noted that it was tested first in mice and non-human primates, and the safety of the treatment and clinical trial was vetted by the National Institutes of Health.
Harmatz said, "The infusion was on Monday. We observed Madeux for 24 hours in the hospital, and he looked fine when he left for his hotel (Tuesday). He hasn't had any problems so far."
One shot at success
Going forward, Harmatz said, he will be monitoring levels of enzymes in Madeux's circulating white blood cells, and in three months, he will perform a liver biopsy to see whether the corrected gene has integrated and started producing enzymes.
"We're very early in testing this first trial," Harmatz said. "I'm hopeful that we'll have some production." Since Madeux has shown no difficulties, Harmatz believes all should continue to go well.
However, he is concerned that the dose "was not enough and it turns out to be ineffective and not a benefit to him. You have one shot, one chance to have an effective therapy."
'Three-parent' babies approved in the UK
He explained that you can't come back in two months with a higher dose delivered and hope you get a better response, because after the first infusion, a patient becomes immune to the virus, so it's no longer an effective delivery system.
"People are working very hard to solve this problem," Harmatz said. Still, in about two or three months, he and Conner should know whether the treatment worked.
Dr. Sanjeev Gupta, a professor of medicine and pathology at Albert Einstein College of Medicine and Montefiore Health System, said "this is an exciting step for a long-awaited holy grail of successful gene therapy that has lasting benefit." Gupta, who was not involved in the study, added that whether the technology will be "effective (in the body) remains to be seen."
Along with the difficulties related to the "viral vectors used to insert gene sequences into cells," Gupta noted that "the biology of liver cells is such that multiple copies of any given gene may exist in a single cell. Whether these multiple gene copies could be corrected in sufficient cell numbers could be a key to treatment outcome here.
Follow CNN Health on Facebook and Twitter
See the latest news and share your comments with CNN Health on Facebook and Twitter.
"But without studies that are carefully conducted, we would not be able to know that," he said.
Conner said Sangamo is continuing to screen Hunter syndrome patients to follow Medeux as participants in the study. Meanwhile, they have begun a clinical trial for a similar gene editing treatment focusing on hemophilia B patients.
"We're very, very excited," Conner said. "I'm honored and humbled by Madeux's decision to participate."
Klein also said that "Brian Madeux is very, very brave." Thankful to Sangamo for championing the cause, she believes this first run of gene therapy is a "leap forward."
"It is a new world of science," Klein said. "Someone needs to be on the front line, and Brian has rose to the occasion."