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Mitochondria: 10 Ways to Boost the Powerhouse of Your Cells to prevent cancer and slow down ageing
- Thread starter ginfreely
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What are mitochondria, and how do they help us? Mitochondria are specialized structures found in cells. They participate in many cellular processes, but their most important function is to extract the energy that is stored in the chemical bonds of nutrients (in the form of electrically charged particles called electrons) and transform it into a form of energy that cells can use to power their activity.
This form of energy is a molecule called ATP (from adenosinetriphosphate), and the process is called cellular respiration. Because mitochondria generate around 90 percent of all ATP produced in the body, they are known as “the powerhouse of the cell.”
When mitochondria work optimally, cells are fueled efficiently, and biological pathways run smoothly. But when mitochondria are dysfunctional, they start to accumulate damage, and cellular processes start to gradually get disrupted.
Mitochondrial dysfunction caused by damage accumulation is actually one of the hallmarks of aging.
This happens naturally with age, but improving mitochondrial fitness, their efficacy in generating energy, and their capacity to avoid or repair damage to their biochemical machinery may contribute to a healthier aging process.
This form of energy is a molecule called ATP (from adenosinetriphosphate), and the process is called cellular respiration. Because mitochondria generate around 90 percent of all ATP produced in the body, they are known as “the powerhouse of the cell.”
When mitochondria work optimally, cells are fueled efficiently, and biological pathways run smoothly. But when mitochondria are dysfunctional, they start to accumulate damage, and cellular processes start to gradually get disrupted.
Mitochondrial dysfunction caused by damage accumulation is actually one of the hallmarks of aging.
Why Is It Important to Boost Mitochondria?
Dysfunctions in the mechanisms of ATP production in our mitochondria, particularly in a pathway called the electron transport chain, increase the production of byproducts called reactive oxygen species (ROS) that can be damaging to mitochondria at high concentrations. Mitochondrial dysfunction creates a rolling snowball of damage that can gradually grow to affect all biological processes in our body.This happens naturally with age, but improving mitochondrial fitness, their efficacy in generating energy, and their capacity to avoid or repair damage to their biochemical machinery may contribute to a healthier aging process.
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10 Ways You Can Boost Mitochondria
1. Calorie Restriction
Reducing calorie intake (through fasting diets, for example) is the most successful approach to enhance longevity. This success can be attributed, at least partially, to an increase in mitochondrial bioenergetic efficiency.Calorie restriction acts as a stress signal that triggers a number of adaptations in mitochondria:
- It improves the activity of the electron transport chain and regulates the production of ROS and oxidative stress.
- It supports mitochondrial quality control mechanisms, responsible for preventing and/or repairing damage.
- It promotes the renewal of the mitochondrial network through the elimination of damaged mitochondria (autophagy) and the production of new mitochondria (biogenesis).
2. Exercise
Exercise requires a great deal of energy to power our muscles. That puts a burden on muscle mitochondria, which signal that energetic demand to the rest of the cell.Muscle cells respond by producing more mitochondria and more mitochondrial enzymes. This increases the respiratory capacity of muscles, i.e., their ability to produce ATP from nutrients to power muscle contraction.
It is an adaptation of our muscle cells to exercise and one of the reasons why exercise performance improves with training. Exercise is also one of the best ways to improve mitochondrial biogenesis and function in aging muscle, helping delay the age-related decline in mitochondrial activity and muscle health.
Pls try NMN. U can get it in Iherb.
I take both NMN and NR
I take both NMN and NR
I just googled seem that NR turned into NMN inside body and NR got breast cancer risk.
Potential Side Effects of NMN in Cancer PatientsWhile NMN has shown promise in various areas of health and wellness, its effects on cancer patients are still being studied. It is important to note that NMN may interfere with the efficacy of certain cancer treatments or even promote cancer progression in some cases.17 Mar 2024
https://www.jinfiniti.com › underst...
https://www.jinfiniti.com › underst...
Understanding the Potential NMN Side Effects in Cancer
3. Mitochondrial Nutrients
There are many nutrients that can help mitochondria do their work and maintain their fitness. Mitochondrial nutrients provide substrates and co-factors that support and/or stimulate mitochondrial enzyme activity, they enhance cellular antioxidant defenses, they scavenge free radicals and protect mitochondria from oxidation, and they protect and repair mitochondrial membranes.Mitochondrial nutrients include B vitamins, minerals, polyphenols and other nutrients, such as L-carnitine, alpha-lipoic acid, coenzyme Q10, pyrroloquinoline quinone and creatine, for example. They can be taken as supplements, or they can be found in natural, unprocessed foods, i.e., fruits and vegetables, nuts and seeds, seafood, and meat.
4. Sleep
The human brain requires a lot of energy, and because of its high metabolic rate, the brain accumulates a lot of metabolic waste. During sleep, the brain gets rid of products that can be toxic to mitochondria.An example is the molecule beta-amyloid. At normal levels, beta-amyloid protects neurons and supports their activity. However, when it accumulates excessively, beta-amyloid becomes harmful to neurons, in particular to their mitochondria, which can trigger neurodegenerative processes.
Because neuronal mitochondria power every brain function, it is very important to avoid this accumulation of toxic waste. Poor sleep damages mitochondria, but a good night’s sleep helps the brain keep mitochondria healthy.
5. Relaxation Techniques
Psychological stress influences physical health, and mitochondria have a key role in this influence. Stress can alter mitochondrial structure and function through stress hormones and other stress signals that are sensed bymitochondria.Chronic stress can cause mitochondrial dysfunctions and modify cellular and biological processes. Stress-induced mitochondrial dysfunctions can be particularly harmful to the nervous, endocrine and immune systems, from which a generalized negative impact on the body can develop.
Therefore, practices that help manage stress — meditation, yoga, tai chi or breathing exercises, for example — may help prevent the effects of stress. In fact, regular practice of relaxation techniques has been shown to upregulate genes that are linked to healthy mitochondrial function.
6. Sunlight
Without forgetting that excessive unprotected sun bathing can be very harmful, it’s important to remember that the right amount of sun is fundamental for our health. A well-known effect of sunlight is the production of vitamin D in our skin.It turns out that vitamin D is necessary for mitochondrial activity and that vitamin D supplementation in vitamin D-deficient adults improves mitochondrial oxidative capacityin muscles. Furthermore, animal studies have shown that vitamin D promotes mitochondrial biogenesis and increases the oxidative capacity of mitochondria in muscles and brown fat.
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7. Red/Near-Infrared Light Therapy
Red and near-infrared light can penetrate the skin and act on mitochondria through stimulation of a molecule called cytochrome C oxidase. This molecule is part of the mitochondrial electron transport chain that produces ATP. Red and near-infrared light enhance the efficiency of the mitochondrial electron transport chain and energy production.By doing so, red/near-infrared light therapy also improves cellular signaling by ROS and triggers cellular changes that lead to beneficial cellular responses, including enhanced antioxidant defenses and improved cellular functioning. A number of benefits have been described for red/near-infrared light therapy, including, for example, accelerated wound healing and increased capacity to decrease muscle damage and improve muscle recoveryfollowing exercise.
8. Cold Exposure
When we’re cold, two types of tissues respond immediately by generating extra heat. One is skeletal muscle, which produces heat through shivering. The other is brown adipose tissue (BAT or brown fat), responsible for non-shivering heat production.Shivering releases heat in the process of burning fuels and using ATP to power muscle contraction. Shivering thus recruits mitochondria to indirectly generate heat.
BAT, unlike other tissues, has a molecule that can uncouple respiration from ATP production and use it instead to actively produce heat. BAT thus uses mitochondria to directly generate heat.
In both skeletal muscle and brown fat, cold stimulates an increase in mitochondrial activity and mitochondrial biogenesis. Therefore, cold exposure in the form of cold showers or cryotherapy can boost mitochondria to keep us warm.
9. Heat Exposure
Heat can also trigger beneficial biological responses. Heat acts as a mild stress signal and triggers cell responses that promote adaptation.One of the main agents of that adaptation are mitochondria, as it has been shown that heat stress triggers beneficial adaptive response in mitochondria that increase their functional capacity.
These effects have been shown inskeletal muscle and cardiac muscle, for example. This stands in line with studies showing that routine sauna bathing can improve endurance performanceand reduce the risk of cardiovascular diseases, for example.
10. Supporting NAD+
NAD+ (from nicotinamide adenine dinucleotide) is a molecule derived from vitamin B3 found in every single cell in the body. NAD+ has a key role in mitochondrial function: It is the main molecule responsible for the delivery of the electrons that are extracted from food to the electron transport chain for ATP production.NAD+ is therefore as important for cells as ATP itself. Consequently, NAD+ is essential for the maintenance of health.
NAD levels decrease naturally in many tissues as we age. This decrease may also contribute to the aging process.
However, we can boost NAD+ levels by supplying cells with nutrients that can help them optimize NAD+ metabolism. Doing so may counterbalance the age-related decrease in NAD+ and help support mitochondrial function, protect against age-related diseases, and support longevity.
Final Thoughts
Mitochondria sustain human life because they generate the energy that powers our cells. By supporting mitochondrial fitness, we are supporting the optimal functioning of pretty much every cell and system in the body.Boosting mitochondria can help us live a long and healthy life.
Sara Adaes, Ph.D., is a neuroscientist and biochemist working as a research scientist at Neurohacker Collective. Sara graduated in Biochemistry at the Faculty of Sciences of the University of Porto, in Portugal. Her first research experience was in the field of neuropharmacology. She then studied the neurobiology of pain at the Faculty of Medicine of the University of Porto, where she got her Ph.D. in Neuroscience. In the meantime, she became interested in science communication and in making scientific knowledge accessible to the lay society. Sara wants to use her scientific training and skills to contribute to increasing the public understanding of science.
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NAD is a vital helper molecule in many cellular activities, such as transferring electrons, repairing DNA, and controlling gene expression. NMN is a unique building block that assists in creating NAD. Its structure consists of nicotinamide, a sugar molecule known as ribose, and a phosphate group.22 Jun 2023
https://donotage.org › blogs › wha...
What is the Difference Between NAD and NMN?
NMN (Nicotinamide mononucleotide) and NR (nicotinamide riboside) are active compounds that can possibly reverse aging. Both NMN and NR are commonly marketed as dietary supplements, popular due to their role in boosting NAD+ levels. Recently, NMN is no longer available to be sold as a supplement in the United States. Can NR serve as a good replacement?
https://healthnews.com/longevity/lo...n-alternative-to-nicotinamide-mononucleotide/
https://healthnews.com/longevity/lo...n-alternative-to-nicotinamide-mononucleotide/
Key takeaways:
Both NMN and NR are NAD+ precursors; hence their supplementation results in increased NAD+ levels. However, one theory is that NMN cannot go directly to cells, while NR can.
NR supplement has various benefits ranging from healthy aging to boosting metabolic performance.
However, NR is unstable and hard to absorb, so liposomal NR delivery is the most effective delivery strategy to raise NAD+ levels in the body.
NMN supplements are now banned in the US due to FDA permission for research as a novel drug.
Some experts believe that NMN must be converted to NR before entering cells, where NAD+ production occurs since it is too big to pass through cellular membranes. Another theory is that Slc12a8, an NMN-specific transporter, may play a role in delivering NMN into cells.
According to a 2007 study, NR significantly increases yeast NAD+ levels and extends lifespan even without caloric restriction. Additional research on the subject shows that NR raises NAD+ in mammalian cells by up to 270%. The two precursors, NMN and NR, are still up for discussion as to which is safer and more effective.
Since NMN may need to be changed into NR first in order to pass through the cell membrane and enter the cell, it is hypothesized that the cell would convert the NR back into NMN for NAD+ synthesis. If this is the case, the more effective compound for supplementation would be NR.
The Relationship Between NMN and Cancer
Now that you know the fundamental aspects of NMN, let’s examine its relationship with cancer. Cancer is a complex disease characterized by uncontrolled cell growth and the ability to evade cell death mechanisms. NMN has been found to influence cancer cell growth through various mechanisms.In addition to modulating NAD+ levels, NMN has also been shown to affect other pathways involved in cancer cell growth. For example, studies have demonstrated that NMN can inhibit the activity of certain enzymes that promote cell division, thereby slowing down the proliferation of cancer cells. Furthermore, NMN has been found to activate tumor suppressor genes, which play a crucial role in preventing the development and progression of cancer.
How NMN Influences Cancer Cell Growth
One way NMN influences cancer cell growth is by modulating NAD+ levels. NAD+ is essential for cell survival and proliferation, making it a critical factor in cancer progression. By supplementing NMN, it is hypothesized that NAD+ levels can be increased, which could potentially enhance cancer cell growth and survival.Conversely, inhibiting NAD+ synthesis through NMN depletion may offer a novel therapeutic strategy for cancer treatment. However, the specific impact of NMN on different types of cancer cells is still being investigated.
Another mechanism through which NMN influences cancer cell growth is by regulating the activity of certain proteins involved in cell cycle progression. NMN has been shown to inhibit the activity of cyclin-dependent kinases, which are enzymes that control the transition between different phases of the cell cycle. By disrupting this process, NMN can effectively halt the uncontrolled growth of cancer cells and promote their death through apoptosis.
NMN and Cancer: The Current Research
Research exploring the role of NMN in cancer treatment is ongoing, and the findings are not definitive. Some studies suggest that NMN supplementation may have beneficial effects on certain types of cancer by enhancing the effectiveness of chemotherapy or radiation therapy. For example, preclinical studies have demonstrated that combining NMN with certain anticancer drugs can lead to increased tumor regression and improved overall survival rates.However, conflicting evidence exists, and more research is required to determine the optimal dosage, treatment duration, and potential risks associated with NMN use in cancer patients. Clinical trials have commenced to address these uncertainties and ascertain the safety and efficacy of NMN as an adjuvant therapy in cancer. These trials involve large cohorts of patients with different types of cancer, allowing researchers to evaluate the effects of NMN on various aspects of cancer progression, such as tumor growth, metastasis, and patient survival.
Furthermore, researchers are also investigating the potential synergistic effects of NMN with other therapeutic agents, such asimmunotherapies and targeted therapies. Combining NMN with these treatments may lead to improved outcomes by enhancing the immune response against cancer cells or by targeting specific molecular pathways that are dysregulated in cancer.
In conclusion, NMN holds promise as a potential therapeutic agent in cancer treatment. Its ability to modulate NAD+ levels and affect various pathways involved in cancer cell growth makes it an intriguing candidate for further investigation. Ongoing research and clinical trials will provide valuable insights into the safety, efficacy, and optimal use of NMN in cancer patients, ultimately paving the way for the development of novel and effective treatment strategies.
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